Gene Symbol | DENND6A |
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Entrez Gene | 201627 |
Alt Symbol | AFI1A, FAM116A |
Species | Human |
Gene Type | protein-coding |
Description | DENN/MADD domain containing 6A |
Other Description | DENN domain-containing protein 6A|family with sequence similarity 116, member A|protein DENND6A|protein FAM116A |
Swissprots | Q8N235 Q8IWF6 Q8TEG8 Q7Z5T4 |
Accessions | EAW65345 EAW65346 Q8IWF6 AA605125 AK074156 BAB84982 AK092288 BAC03852 BC040291 AAH40291 BC054343 AAH54343 DB163127 JF432855 ADZ16072 XM_006713019 XP_006713082 XM_006713020 XP_006713083 XM_011533476 XP_011531778 XR_245100 NM_152678 NP_689891 |
Function | Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}. |
Subcellular Location | Recycling endosome {ECO:0000269|PubMed:22595670}. Cytoplasm {ECO:0000269|PubMed:22595670}. |
FAM116A CRISPR/Cas9 KO Plasmid (h) - sc-415019 from Santa Cruz Biotechnology
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FAM116A HDR Plasmid (h) - sc-415019-HDR from Santa Cruz Biotechnology
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FAM116A Double Nickase Plasmid (h) - sc-415019-NIC from Santa Cruz Biotechnology
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FAM116A Double Nickase Plasmid (h2) - sc-415019-NIC-2 from Santa Cruz Biotechnology
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FAM116A CRISPR Activation Plasmid (h) - sc-415019-ACT from Santa Cruz Biotechnology
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FAM116A CRISPR Activation Plasmid (h2) - sc-415019-ACT-2 from Santa Cruz Biotechnology
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FAM116A Lentiviral Activation Particles (h) - sc-415019-LAC from Santa Cruz Biotechnology
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FAM116A Lentiviral Activation Particles (h2) - sc-415019-LAC-2 from Santa Cruz Biotechnology
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FAM116A siRNA (h) - sc-77957 from Santa Cruz Biotechnology
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FAM116A shRNA Plasmid (h) - sc-77957-SH from Santa Cruz Biotechnology
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FAM116A shRNA (h) Lentiviral Particles - sc-77957-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8134 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8134 from Sigma-Aldrich
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DENND6A siRNA (Human) - CRJ6301 from Cohesion Biosciences
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DENND6A - MBS8234298 from MyBioSource
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shRNA set against Human FAM116A (NM_152678.2) - SHH289213 from Creative biogene
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Human DENND6A siRNA - orb276802 from Biorbyt
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DENND6A shRNA Plasmid (Human) - CHJ6301 from Cohesion Biosciences
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DENND6A miRNA 3'UTR clone - MiUTR4H-TG03351 from Creative biogene
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