| Gene Symbol |
LZTFL1
|
| Entrez Gene |
54585
|
| Alt Symbol |
BBS17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine zipper transcription factor-like 1
|
| Other Description |
leucine zipper transcription factor-like protein 1
|
| Swissprots |
Q9NQ48 B4E0K7 Q9NQ56 Q8TC61 B3KSI9
|
| Accessions |
CAB96873 EAW64749 EAW64750 Q9NQ48 AJ297351 CAB95836 AK024323 AK027165 AK093705 BAG52751 AK129805 AK303416 BAG64469 BC025988 AAH25988 BC042483 AAH42483 BX112707 BX640604 CAE45710 CN429018 DA408809 DC410047 EU176533 ABW03334 HY159348 XM_006713207 XP_006713270 XM_011533838 XP_011532140 XM_011533839 XP_011532141 NM_001276378 NP_001263307 NM_001276379 NP_001263308 NM_020347 NP_065080 NR_075080
|
| Function |
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:22510444}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986}.
|
| Tissue Specificity |
Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, spleen, small intestine, and peripheral blood leukocytes. {ECO:0000269|PubMed:11352561, ECO:0000269|PubMed:20233871}.
|