| Gene Symbol |
STAT3
|
| Entrez Gene |
6774
|
| Alt Symbol |
ADMIO, APRF, HIES
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal transducer and activator of transcription 3 (acute-phase response factor)
|
| Other Description |
DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
|
| Swissprots |
Q9BW54 P40763 A8K7B8 K7ENL3 O14916
|
| Accessions |
AAK17196 AAS66986 CBY84972 CCA94578 EAW60820 EAW60821 EAW60822 EAW60823 EAW60824 EAW60825 EAW60826 EAW60827 P40763 AB451232 BAG70046 AF029311 AAB84254 AI631896 AJ012463 CAA10032 AK024535 AK092965 AK291933 BAF84622 AK297994 BAG60302 AK301200 BAG62778 AK316139 BAH14510 AM393108 CAL37986 BC000627 AAH00627 BC008044 BC014482 AAH14482 BC029783 BC067119 BC107775 BI461226 CB216860 CB321646 CF454565 EU446657 ABZ92186 EU831439 ACE87126 EU831531 ACE86450 L29277 AAA58374 XM_005257616 XP_005257673 XM_005257617 XP_005257674 XM_011525145 XP_011523447 XM_011525146 XP_011523448 NM_003150 NP_003141 NM_139276 NP_644805 NM_213662 NP_998827
|
| Function |
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
|
| Tissue Specificity |
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
Inflammatory bowel disease (IBD), Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Proteoglycans in cancer
|
