STAT3

Gene Symbol	STAT3
Entrez Gene	6774
Alt Symbol	ADMIO, APRF, HIES
Species	Human
Gene Type	protein-coding
Description	signal transducer and activator of transcription 3 (acute-phase response factor)
Other Description	DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
Swissprots	Q9BW54 P40763 A8K7B8 K7ENL3 O14916
Accessions	AAK17196 AAS66986 CBY84972 CCA94578 EAW60820 EAW60821 EAW60822 EAW60823 EAW60824 EAW60825 EAW60826 EAW60827 P40763 AB451232 BAG70046 AF029311 AAB84254 AI631896 AJ012463 CAA10032 AK024535 AK092965 AK291933 BAF84622 AK297994 BAG60302 AK301200 BAG62778 AK316139 BAH14510 AM393108 CAL37986 BC000627 AAH00627 BC008044 BC014482 AAH14482 BC029783 BC067119 BC107775 BI461226 CB216860 CB321646 CF454565 EU446657 ABZ92186 EU831439 ACE87126 EU831531 ACE86450 L29277 AAA58374 XM_005257616 XP_005257673 XM_005257617 XP_005257674 XM_011525145 XP_011523447 XM_011525146 XP_011523448 NM_003150 NP_003141 NM_139276 NP_644805 NM_213662 NP_998827
Function	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Inflammatory bowel disease (IBD), Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human STAT3 full length protein - ab43618 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human STAT3 full length protein - ab82053 from Abcam Category Protein Source E. coli Species Human

Human STAT3 peptide - ab102062 from Abcam Category Peptide Species Human

Human STAT3 peptide - ab23064 from Abcam Category Peptide Species Human

Human STAT3 protein fragment - ab173066 from Abcam Category Protein Source E. coli Species Human

STAT3 (phospho Y705) peptide - ab179551 from Abcam Category Peptide

STAT3 peptide - ab8001 from Abcam Category Peptide

STAT3 Antibody Blocking Peptide - LS-E3803 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E5559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E10558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E10651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E7322 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E7323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E31390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STAT3 Antibody Blocking Peptide - LS-E13739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAT3 Antibody Blocking Peptide - LS-E26153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human STAT3 Protein - H00006774-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human STAT3 Protein - H00006774-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NFkB p105/STAT3 Peptide - NBP1-96923 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

Phospho-STAT3S727-Antibody-Blocking-peptide - BP1534a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

STAT3-Antibody-C-term-S727-Blocking-Peptide - BP18086b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-STAT3Y705-Antibody-Blocking-peptide - BP3261a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-STAT3S727-Antibody-Blocking-peptide - BP3260a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

STAT3 (isoform 1 and 2) blocking peptide - GTX25073-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

STAT3 blocking peptide - GTX89276-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

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