STAT3

Gene Symbol STAT3
Entrez Gene 6774
Alt Symbol ADMIO, APRF, HIES
Species Human
Gene Type protein-coding
Description signal transducer and activator of transcription 3 (acute-phase response factor)
Other Description DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
Swissprots Q9BW54 P40763 A8K7B8 K7ENL3 O14916
Accessions AAK17196 AAS66986 CBY84972 CCA94578 EAW60820 EAW60821 EAW60822 EAW60823 EAW60824 EAW60825 EAW60826 EAW60827 P40763 AB451232 BAG70046 AF029311 AAB84254 AI631896 AJ012463 CAA10032 AK024535 AK092965 AK291933 BAF84622 AK297994 BAG60302 AK301200 BAG62778 AK316139 BAH14510 AM393108 CAL37986 BC000627 AAH00627 BC008044 BC014482 AAH14482 BC029783 BC067119 BC107775 BI461226 CB216860 CB321646 CF454565 EU446657 ABZ92186 EU831439 ACE87126 EU831531 ACE86450 L29277 AAA58374 XM_005257616 XP_005257673 XM_005257617 XP_005257674 XM_011525145 XP_011523447 XM_011525146 XP_011523448 NM_003150 NP_003141 NM_139276 NP_644805 NM_213662 NP_998827
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways Inflammatory bowel disease (IBD), Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Proteoglycans in cancer

PathScan ® Phospho-Stat3 (Tyr705) Sandwich ELISA Kit - 7300 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-Stat3 (Tyr705) Chemiluminescent Sandwich ELISA Kit - 7149 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit ((96 assays) Low Volume Microplate)

PathScan ® Phospho-Stat3 (Tyr705) Sandwich ELISA Antibody Pair - 7146 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Total Stat3 Sandwich ELISA Kit - 7305 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-Stat3 (Ser727) Sandwich ELISA Kit - 7995 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-Stat3 (Ser727) Chemiluminescent Sandwich ELISA Kit - 8026 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

STAT3 (pY705) + Total SimpleStep ELISA™ Kit - ab176666 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Example of a typical STAT3 (pY705) and STAT3 (Total) cell lysate dilution series. Background-subtracted data values (mean +/- SD) are graphed.

STAT3 (pY705) + total STAT3 ELISA Kit - ab126459 from Abcam

Category ELISA Kit
Prices $499.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant human EGF at 37°C for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

STAT3 (pY705) ELISA Kit - ab126458 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
A431 cells were treated with recombinant human EGF at 37°C for 20 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

STAT3 (pY705) PhosphoTracer ELISA Kit - ab119650 from Abcam

Category ELISA Kit
Sensitivity 50 µg protein/ml
Range 50 µg protein/ml - 1000 µg protein/ml
As shown, using the STAT3 assay kits, a significant stimulation of STAT3 phosphorylation at Tyr705 is detected in A431 cells treated with EGF for 10 minutes compared with cells treated with AG1478, while a change in total STAT3 levels is also observed.

STAT3 (pY705) SimpleStep ELISA™ Kit - ab176654 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity < 30 µg/ml
Range 30 µg/ml - 3000 µg/ml
Example of a typical STAT3 (pY705) cell lysate dilution series. Raw data values are shown in the table. Background-subtracted data values (mean +/- SD) are graphed.

STAT3 (Tyr705) In-Cell ELISA Kit - ab126427 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
A431 cells were stimulated by different concentrations of EGF for 10 minutes at 37°C.

STAT3 pTyr705 + Total PhosphoTracer ELISA kit - ab119672 from Abcam

Category ELISA Kit
Sensitivity 50 µg protein/ml
Range 50 µg protein/ml - 1000 µg protein/ml
Using Western blot, a significant stimulation of STAT3 phosphorylation at Tyr705 is detected in A431 cells treated with EGF for 10 minutes (Lane 2) compared with cells treated with AG1478 (Lane 1), while a change in total STAT3 levels is also observed (Lane 3, 4).

STAT3 Total PhosphoTracer ELISA Kit - ab119651 from Abcam

Category ELISA Kit
Sensitivity 50 µg protein/ml
Range 50 µg protein/ml - 1000 µg protein/ml
Using Western blot, a significant stimulation of STAT3 phosphorylation at Tyr705 is detected in A431 cells treated with EGF for 10 minutes (+) compared with cells treated with AG1478 (-), while a change in total STAT3 levels is also observed.

STAT3 Total SimpleStep ELISA™ Kit - ab176655 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity < 15 µg/ml
Range 15 µg/ml - 1500 µg/ml
Example of a typical STAT3 cell lysate dilution series. Raw data values are shown in the table. Background-subtracted data values (mean +/- SD) are graphed.

Rabbit anti-STAT3 Antibody, Affinity Purified - PLA0255 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Phosphotyrosine STAT3 / Signal Transducer and Activator of Transcription 3 ELISA Kit - RAB0995 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Phospho-Stat3 (pTyr705) ELISA Kit - RAB0446 from Sigma-Aldrich

Category ELISA Kit
Prices $522.00
Sizes 1 kt

Mouse/Human/Rat STAT3 ELISA Kit (Cell-Based ELISA) - LS-F2328 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.312-20 ng/ml

Human STAT3 ELISA Kit - LS-F4933 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.06 ng/ml
Range 0.156 - 10 ng/ml

Mouse/Human/Rat STAT3 ELISA Kit (DNA-Binding ELISA) - LS-F819 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Range 0.312-20 ng/ml

Mouse/Human/Rat Phospho-STAT3 (Tyr705) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F949 from LifeSpan Bioscience

Category ELISA Kit
Prices $440.00, $820.00, $1,910.00
Sizes 1 plate, 2 plate, 5 plate
Range 0.312-20 ng/ml

Mouse/Human/Rat Phospho-STAT3 (Ser727) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1624 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.312-20 ng/ml

Mouse/Human/Rat Phospho-STAT3 (Tyr705) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1625 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.312-20 ng/ml

Rat STAT3 ELISA Kit - LS-F7839 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.054 ng/ml
Range 0.156 - 10 ng/ml
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