STAT3

Gene Symbol STAT3
Entrez Gene 6774
Alt Symbol ADMIO, APRF, HIES
Species Human
Gene Type protein-coding
Description signal transducer and activator of transcription 3 (acute-phase response factor)
Other Description DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
Swissprots Q9BW54 P40763 A8K7B8 K7ENL3 O14916
Accessions AAK17196 AAS66986 CBY84972 CCA94578 EAW60820 EAW60821 EAW60822 EAW60823 EAW60824 EAW60825 EAW60826 EAW60827 P40763 AB451232 BAG70046 AF029311 AAB84254 AI631896 AJ012463 CAA10032 AK024535 AK092965 AK291933 BAF84622 AK297994 BAG60302 AK301200 BAG62778 AK316139 BAH14510 AM393108 CAL37986 BC000627 AAH00627 BC008044 BC014482 AAH14482 BC029783 BC067119 BC107775 BI461226 CB216860 CB321646 CF454565 EU446657 ABZ92186 EU831439 ACE87126 EU831531 ACE86450 L29277 AAA58374 XM_005257616 XP_005257673 XM_005257617 XP_005257674 XM_011525145 XP_011523447 XM_011525146 XP_011523448 NM_003150 NP_003141 NM_139276 NP_644805 NM_213662 NP_998827
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways Inflammatory bowel disease (IBD), Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Proteoglycans in cancer

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 4323 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3A7
Flow cytometric analysis of Jurkat cells, untreated (blue) or IFN-α treated (green), using Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) #4323 compared to nonspecific control antibody (red).

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 4324 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3A7
Flow cytometric analysis of Jurkat cells, untreated (blue) or IFN-α treated (green), using Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate).

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (PE Conjugate) - 8119 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3A7
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with hIFN-α1 #8927 (green), using Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (PE Conjugate).

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Biotinylated) - 4093 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3A7
Western blot analysis of extracts from HeLa cells, untreated or IFN-α-treated, using Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.

Stat3 (D3Z2G) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 14047 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3Z2G
Confocal immunofluorescent analysis of HeLa cells (serum-starved overnight), untreated (upper left) or treated with Human Interferon-α1 (hIFN-α1) (1,000 units/ml, 30 min; upper right), and PC-3 cells (serum-starved overnight), untreated (lower left) or treated with Human Interferon-α1 (hIFN-α1) (1,000 units/ml, 30 min; lower right), using Stat3 (D3Z2G) Rabbit mAb (Alexa Fluor® 488 Conjugate) (green) and β-Actin (8H10D10) Mouse mAb #3700 (red).

Stat3 (D3Z2G) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 14062 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3Z2G
Flow cytometic analysis of PC-3 (blue) and HeLa (green) cells using Stat3 (D3Z2G) Rabbit mAb (Alexa Fluor ® 647 Conjugate).

Stat3 (79D7) Rabbit mAb (Biotinylated) - 8232 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 79D7
Western blot analysis of extracts from NIH/3T3 and HeLa cells using Stat3 (79D7) Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.

Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb - 9145 from Cell Signaling Technology

Prices $119.00, $318.00, $750.00
Sizes 20 µl (2 western blots), 100 µl (20 western blots), 300 µl (60 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3A7
Western blot analysis of extracts from IFN-alpha treated Jurkat cells and HeLa cells (left), as well as EGF treated A431 cells (right), using Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb. Note that the basal phospho-Stat3 in A431 is detected by the antibody.

Phospho-Stat3 (Tyr705) (M9C6) Mouse mAb - 4113 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone M9C6
Western blot analysis of extracts from HeLa cells, untreated or treated with IFN-α (100 ng/ml) for 5 minutes, using Phospho-Stat3 (Tyr705) (M9C6) Mouse mAb (left) or Stat3 Antibody #9132 (right).

Phospho-Stat3 (Ser727) Antibody - 9134 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A172 cells, untreated (-) or UV-treated (100 mJ, 30 min; +) with or without λ phosphatase (+), using Phospho-Stat3 (Ser727) Antibody (upper) and Stat3 (79D7) Rabbit mAb #4904 (lower).

Phospho-Stat3 (Tyr705) (3E2) Mouse mAb - 9138 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Mouse
Clonality Monoclonal
Clone 3E2
Western blot analysis of extracts from HeLa cells, untreated or IFN-alpha-treated (100 ng/ml), using Phospho-Stat3 (Tyr705) (3E2) Mouse mAb.

Phospho-Stat3 (Tyr705) Antibody - 9131 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CNTF-treated SK-N-MC cells and EGF-treated A431 cells, using Phospho-Stat3 (Tyr705) Antibody (upper) or Stat3 Antibody #9132 (lower).

Phospho-Stat3 (Ser727) (6E4) Mouse mAb - 9136 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 6E4
Western blot analysis of extracts from serum-starved HeLa cells, untreated or IL-6-treated (100 ng/ml), using Phospho-Stat3 (Ser727) (6E4) Mouse mAb.

PhosphoPlus ® Stat3 (Tyr705) Antibody Kit - 9130 from Cell Signaling Technology

Prices $489.00
Sizes 1 kit (10 western blots)
Clonality Polyclonal

Acetyl-Stat3 (Lys685) Antibody - 2523 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells transfected with Stat3, CBP or both, using Acetyl-Stat3 (Lys685) Antibody (top) or total Stat3 Antibody #9139.

Stat3α (D1A5) XP ® Rabbit mAb - 8768 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1A5
Western blot analysis of extracts from various cell lines using Stat3α (D1A5) XP ® Rabbit mAb (top), Stat3 (124H6) Mouse mAb #9139 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Stat3α Antibody - 8719 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Stat3α Antibody (upper) or Stat3 (124H6) Mouse mAb #9139 (lower).

Stat3 (124H6) Mouse mAb - 9139 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 124H6
Western blot analysis of extracts from HeLa, NIH/3T3, PC12 and COS cells, using Stat3 (124H6) Mouse mAb.

Stat3 (D3Z2G) Rabbit mAb - 12640 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Z2G
Western blot analysis of extracts from various cell lines using Stat3 (D3Z2G) Rabbit mAb (upper), or β-Actin (D6A8) Rabbit mAb #8457 (lower). PC-3 cells are negative for Stat3.

Stat3 (79D7) Rabbit mAb - 4904 from Cell Signaling Technology

Prices $99.00, $256.00
Sizes 20 µl (2 western blots), 100 µl (20 western blots)
Host Rabbit
Clonality Monoclonal
Clone 79D7
Western blot analysis of extracts from various cell lines using Stat3 (79D7) Rabbit mAb.

Phospho-Stat3 (Tyr705) Antibody - 5185 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Phospho-Stat3 (Tyr705) (58E12) Rabbit mAb - 9135 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 58E12

Phospho-Stat3 (Ser727) (6E4) Mouse mAb - 5190 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 6E4

Stat3 (7D1) Mouse mAb - 9137 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 7D1

Stat3 Antibody - 9132 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
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