| Gene Symbol |
SERTAD2
|
| Entrez Gene |
9792
|
| Alt Symbol |
Sei-2, TRIP-Br2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SERTA domain containing 2
|
| Other Description |
SERTA domain-containing protein 2|transcriptional regulator interacting with the PHD-bromodomain 2|transcriptional regulator interacting with the PHS-bromodomain 2
|
| Swissprots |
Q14140 Q53TS2
|
| Accessions |
AAY14766 EAW99935 Q14140 AK124032 AK311117 BC074788 AAH74788 BC074789 AAH74789 BC101639 AAI01640 BC101641 AAI01642 BQ017415 D50917 BAA09476 EU446753 ABZ92282 XM_005264669 XP_005264726 XM_011533204 XP_011531506 XM_011533205 XP_011531507 NM_014755 NP_055570
|
| Function |
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F- target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269|PubMed:11331592}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18316374}. Cytoplasm {ECO:0000269|PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
|
| Tissue Specificity |
Expressed in adipose tissue. {ECO:0000269|PubMed:23291629}.
|