Gene Symbol | SERTAD2 |
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Entrez Gene | 9792 |
Alt Symbol | Sei-2, TRIP-Br2 |
Species | Human |
Gene Type | protein-coding |
Description | SERTA domain containing 2 |
Other Description | SERTA domain-containing protein 2|transcriptional regulator interacting with the PHD-bromodomain 2|transcriptional regulator interacting with the PHS-bromodomain 2 |
Swissprots | Q14140 Q53TS2 |
Accessions | AAY14766 EAW99935 Q14140 AK124032 AK311117 BC074788 AAH74788 BC074789 AAH74789 BC101639 AAI01640 BC101641 AAI01642 BQ017415 D50917 BAA09476 EU446753 ABZ92282 XM_005264669 XP_005264726 XM_011533204 XP_011531506 XM_011533205 XP_011531507 NM_014755 NP_055570 |
Function | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F- target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269|PubMed:11331592}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18316374}. Cytoplasm {ECO:0000269|PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome. |
Tissue Specificity | Expressed in adipose tissue. {ECO:0000269|PubMed:23291629}. |
SERTAD2 (B-22) - sc-133992 from Santa Cruz Biotechnology
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Anti-SERTAD2 antibody - ab169378 from Abcam
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Anti-SERTAD2 antibody - ab68037 from Abcam
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Anti-SERTAD2 antibody - N-terminal - ab173603 from Abcam
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Anti-SERTAD2 Antibody (aa1-30, AP) - LS-C269050 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa43-92) - LS-C81654 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30, APC) - LS-C269051 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30, Biotin) - LS-C269052 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30, FITC) - LS-C269053 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30, PE) - LS-C269054 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa35-84) - LS-C102391 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30, Azide-free, HRP) - LS-C269055 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30) - LS-C325018 from LifeSpan Bioscience
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Anti-SERTAD2 Antibody (aa1-30) - LS-C158952 from LifeSpan Bioscience
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SERTAD2 Antibody - NBP1-81541 from Novus Biologicals
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SERTAD2 Antibody - NBP1-81542 from Novus Biologicals
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SERTAD2 Antibody - NBP1-79455 from Novus Biologicals
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SERTAD2 Antibody - NBP1-79454 from Novus Biologicals
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SERTAD2 Antibody - H00009792-B01 from Novus Biologicals
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SERTAD2 Antibody - H00009792-B01P from Novus Biologicals
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SERTAD2 Polyclonal Antibody - bs-6398R from Bioss
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Anti-SERTAD2 antibody produced in mouse - SAB1406882 from Sigma-Aldrich
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Anti-SERTAD2 antibody produced in rabbit - HPA019021 from Sigma-Aldrich
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Anti-SerTAD2 antibody produced in rabbit - AV51655 from Sigma-Aldrich
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SERTAD2 antibody - N-terminal region (ARP51654_P050) - ARP51654_P050 from Aviva Systems Biology
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