| Gene Symbol |
NACA
|
| Entrez Gene |
4666
|
| Alt Symbol |
HSD48, NACA1, skNAC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nascent polypeptide-associated complex alpha subunit
|
| Other Description |
NAC-alpha|alpha-NAC, muscle-specific form|nascent polypeptide-associated complex subunit alpha|nascent-polypeptide-associated complex alpha polypeptide
|
| Swissprots |
Q53A18 A8MTN7 Q53G46 Q3KQV4 B2R4P8 F8VU71 Q13765 E9PAV3
|
| Accessions |
E9PAV3 EAW96960 EAW96961 Q13765 AF054187 AAC99403 AK090650 BAG52208 AK096699 AK223085 BAD96805 AK293209 BAG56749 AK311904 BAG34845 AY034001 AAK57544 AY605660 AAV83778 AY911673 AAX14393 BC105120 AAI05121 BC105122 AAI05123 BC106041 AAI06042 BG709003 CD246364 CR450295 CAG29291 DB487006 X80909 CAA56869 XM_006719412 XP_006719475 XM_006719413 XP_006719476 XM_006719414 XP_006719477 XM_006719418 XP_006719481 XM_006719419 XP_006719482 XM_006719420 XP_006719483 XM_006719421 XP_006719484 XM_011538389 XP_011536691 NM_001113202 NP_001106673 NM_001113203 NP_001106674 NR_045277 NM_001113201 NM_005594
|
| Function |
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:16201836}.
|