NACA

Gene Symbol NACA
Entrez Gene 4666
Alt Symbol HSD48, NACA1, skNAC
Species Human
Gene Type protein-coding
Description nascent polypeptide-associated complex alpha subunit
Other Description NAC-alpha|alpha-NAC, muscle-specific form|nascent polypeptide-associated complex subunit alpha|nascent-polypeptide-associated complex alpha polypeptide
Swissprots Q53A18 A8MTN7 Q53G46 Q3KQV4 B2R4P8 F8VU71 Q13765 E9PAV3
Accessions E9PAV3 EAW96960 EAW96961 Q13765 AF054187 AAC99403 AK090650 BAG52208 AK096699 AK223085 BAD96805 AK293209 BAG56749 AK311904 BAG34845 AY034001 AAK57544 AY605660 AAV83778 AY911673 AAX14393 BC105120 AAI05121 BC105122 AAI05123 BC106041 AAI06042 BG709003 CD246364 CR450295 CAG29291 DB487006 X80909 CAA56869 XM_006719412 XP_006719475 XM_006719413 XP_006719476 XM_006719414 XP_006719477 XM_006719418 XP_006719481 XM_006719419 XP_006719482 XM_006719420 XP_006719483 XM_006719421 XP_006719484 XM_011538389 XP_011536691 NM_001113202 NP_001106673 NM_001113203 NP_001106674 NR_045277 NM_001113201 NM_005594
Function Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}.
Subcellular Location Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:16201836}.

NACA1 CRISPR/Cas9 KO Plasmid (h) - sc-408139 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 HDR Plasmid (h) - sc-408139-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 Double Nickase Plasmid (h) - sc-408139-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 Double Nickase Plasmid (h2) - sc-408139-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 CRISPR Activation Plasmid (h) - sc-408139-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 CRISPR Activation Plasmid (h2) - sc-408139-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 Lentiviral Activation Particles (h) - sc-408139-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 Lentiviral Activation Particles (h2) - sc-408139-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NACA1 siRNA (h) - sc-95918 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NACA1 shRNA Plasmid (h) - sc-95918-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NACA1 shRNA (h) Lentiviral Particles - sc-95918-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057971 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14920 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14920 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NACA siRNA (Human) - CRH3084 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NACA siRNA (Human) - CRH3085 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NACA shRNA Plasmid (Human) - CHH3084 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NACA shRNA Plasmid (Human) - CHH3085 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NACA miRNA 3'UTR clone - MiUTR3H-03967 from Creative biogene

Species Reactivities Human

NACA miRNA 3'UTR clone - MiUTR3H-03968 from Creative biogene

Species Reactivities Human
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