TRAF3

Gene Symbol	TRAF3
Entrez Gene	7187
Alt Symbol	CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated factor 3
Other Description	CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1
Swissprots	Q9UNL1 Q13076 Q13114 Q12990 B7Z8C4 Q13947 Q6AZX1
Accessions	EAW81795 EAW81796 EAW81797 Q13114 AF110908 AAD29276 AK303172 BAH13910 BC075086 AAH75086 BC075087 AAH75087 BQ000015 BX247977 CAD62311 L38509 AAA68195 U15637 AAA56753 U19260 AAA65732 U21092 AAC50112 XM_011537116 XP_011535418 XM_011537117 XP_011535419 XM_011537118 XP_011535420 XR_943512 NM_001199427 NP_001186356 NM_003300 NP_003291 NM_145725 NP_663777 NM_145726 NP_663778
Function	Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubM
Subcellular Location	Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.
Top Pathways	Hepatitis C, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRAF3 293T Cell Transient Overexpression Lysate(Denatured) - H00007187-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TRAF3 overexpression lysate - LY403439 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TRAF3 overexpression lysate - LY418781 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TRAF3 293 Cell Lysate - 408778 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TRAF3 293 Cell Lysate - 402983 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TRAF-3 Overexpression Lysate (Denatured) - H00007187-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

TRAF-3 Overexpression Lysate (Native) - NBL1-17241 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRAF-3 Overexpression Lysate (Native) - NBL1-17242 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRAF3 Over-expression Lysate Product - GWB-6F96F5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

TRAF3 Over-expression Lysate Product - GWB-5CC821 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

TRAF-3 Overexpression Lysate (Denatured) - H00007187-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human TRAF3 Knockdown Stable Cell Line - CSC-DC016514 from Creative biogene Category Cell Line Species Human

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