| Gene Symbol |
TRAF3
|
| Entrez Gene |
7187
|
| Alt Symbol |
CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 3
|
| Other Description |
CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1
|
| Swissprots |
Q9UNL1 Q13076 Q13114 Q12990 B7Z8C4 Q13947 Q6AZX1
|
| Accessions |
EAW81795 EAW81796 EAW81797 Q13114 AF110908 AAD29276 AK303172 BAH13910 BC075086 AAH75086 BC075087 AAH75087 BQ000015 BX247977 CAD62311 L38509 AAA68195 U15637 AAA56753 U19260 AAA65732 U21092 AAC50112 XM_011537116 XP_011535418 XM_011537117 XP_011535419 XM_011537118 XP_011535420 XR_943512 NM_001199427 NP_001186356 NM_003300 NP_003291 NM_145725 NP_663777 NM_145726 NP_663778
|
| Function |
Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubM
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.
|
| Top Pathways |
Hepatitis C, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Herpes simplex infection, Viral carcinogenesis
|