TRAF3
| Gene Symbol | TRAF3 |
|---|---|
| Entrez Gene | 7187 |
| Alt Symbol | CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNF receptor-associated factor 3 |
| Other Description | CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1 |
| Swissprots | Q9UNL1 Q13076 Q13114 Q12990 B7Z8C4 Q13947 Q6AZX1 |
| Accessions | EAW81795 EAW81796 EAW81797 Q13114 AF110908 AAD29276 AK303172 BAH13910 BC075086 AAH75086 BC075087 AAH75087 BQ000015 BX247977 CAD62311 L38509 AAA68195 U15637 AAA56753 U19260 AAA65732 U21092 AAC50112 XM_011537116 XP_011535418 XM_011537117 XP_011535419 XM_011537118 XP_011535420 XR_943512 NM_001199427 NP_001186356 NM_003300 NP_003291 NM_145725 NP_663777 NM_145726 NP_663778 |
| Function | Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubM |
| Subcellular Location | Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}. |
| Top Pathways | Hepatitis C, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Herpes simplex infection, Viral carcinogenesis |
Active human TRAF3 peptide - ab40030 from Abcam
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Human TRAF3 full length protein - ab132121 from Abcam
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Human TRAF3 protein fragment - ab152765 from Abcam
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Recombinant Human TRAF-3 Protein - H00007187-Q01 from Novus Biologicals
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TRAF-3 Recombinant Protein - H00007187-P01 from Novus Biologicals
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TRAF-3 Blocking Peptide - NBP1-76642PEP from Novus Biologicals
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TRAF-3 Peptide - NBP1-76423PEP from Novus Biologicals
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TRAF3-Antibody-C-term-Blocking-peptide - BP13945b from Abgent, a WuXi AppTec company
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TRAF3 Blocking Peptide - 33R-10806 from Fitzgerald
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TRAF3 Blocking Peptide - abx063390 from Abbexa
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TRAF3 / CRAF1 - H00007187-P01-10 from Acris Antibodies
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TRAF3 / CRAF1 - H00007187-P01-25 from Acris Antibodies
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TRAF3 / CRAF1 - H00007187-Q01-10 from Acris Antibodies
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TRAF3 / CRAF1 - H00007187-Q01-25 from Acris Antibodies
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TRAF3 / CRAF1 Control Peptide - AP30936CP-N from Acris Antibodies
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TRAF3 / CRAF1 Control Peptide - AP30937CP-N from Acris Antibodies
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TRAF3 Peptide - 3601P from ProSci
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TRAF3 Peptide - 3599P from ProSci
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TRAF3 fusion protein - ag12185 from Proteintech Group
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TRAF3 fusion protein - ag12406 from Proteintech Group
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Recombinant Human TRAF3, GST-tagged - TRAF3-3384H from Creative Biomart
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Recombinant Human TRAF3, GST-tagged - TRAF3-3385H from Creative Biomart
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Recombinant Human TRAF3, GST-tagged - TRAF3-3386H from Creative Biomart
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Recombinant Human TRAF3, MYC/DDK-tagged - TRAF3-3387H from Creative Biomart
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Recombinant TNF Receptor Associated Factor 3 (TRAF3) - RPG753Hu01 from Uscn Life Science Inc.
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