TRAF3

Gene Symbol TRAF3
Entrez Gene 7187
Alt Symbol CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
Species Human
Gene Type protein-coding
Description TNF receptor-associated factor 3
Other Description CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1
Swissprots Q9UNL1 Q13076 Q13114 Q12990 B7Z8C4 Q13947 Q6AZX1
Accessions EAW81795 EAW81796 EAW81797 Q13114 AF110908 AAD29276 AK303172 BAH13910 BC075086 AAH75086 BC075087 AAH75087 BQ000015 BX247977 CAD62311 L38509 AAA68195 U15637 AAA56753 U19260 AAA65732 U21092 AAC50112 XM_011537116 XP_011535418 XM_011537117 XP_011535419 XM_011537118 XP_011535420 XR_943512 NM_001199427 NP_001186356 NM_003300 NP_003291 NM_145725 NP_663777 NM_145726 NP_663778
Function Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubM
Subcellular Location Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.
Top Pathways Hepatitis C, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Herpes simplex infection, Viral carcinogenesis

TRAF3 CRISPR/Cas9 KO Plasmid (h) - sc-400473 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 HDR Plasmid (h) - sc-400473-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 Double Nickase Plasmid (h) - sc-400473-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 Double Nickase Plasmid (h2) - sc-400473-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 CRISPR Activation Plasmid (h) - sc-400473-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 CRISPR Activation Plasmid (h2) - sc-400473-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 Lentiviral Activation Particles (h) - sc-400473-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 Lentiviral Activation Particles (h2) - sc-400473-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAF3 siRNA (h) - sc-29510 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF3 shRNA Plasmid (h) - sc-29510-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF3 shRNA (h) Lentiviral Particles - sc-29510-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF3 siRNA (h2) - sc-44277 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF3 shRNA Plasmid (h2) - sc-44277-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF3 shRNA (h2) Lentiviral Particles - sc-44277-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAF-3 RNAi - H00007187-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

TRAF-3 RNAi - H00007187-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TRAF-3 RNAi - H00007187-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU092501 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21905 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21905 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TRAF3 siRNA (Human) - CRH4936 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRAF3 - MBS8237829 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRAF3 (NM_003300.3) - SHH433700 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRAF3 siRNA - orb265438 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRAF3 shRNA Plasmid (Human) - CHH4936 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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