SIRT6

Gene Symbol	SIRT6
Entrez Gene	51548
Alt Symbol	SIR2L6
Species	Human
Gene Type	protein-coding
Description	sirtuin 6
Other Description	NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6|sir2-related protein type 6|sirtuin type 6
Swissprots	Q6PK99 B2RCD0 Q8N6T7 Q8NCD2 Q9BSI5 Q9UQD1 O75291 Q6IAF5 Q9NRC7 Q9BWP3
Accessions	AAC34468 AAD15478 CAL00161 EAW69251 EAW69252 EAW69253 EAW69254 EAW69255 EAW69256 EAW69257 EAW69258 EAW69259 Q8N6T7 AF233396 AAF43432 AK074810 BAC11222 AK225567 AK293348 BAG56864 AK299420 BAH13027 AK301247 BAG62814 AK315048 BAG37527 AL365375 BC004218 AAH04218 BC005026 AAH05026 BC028220 AAH28220 CR457200 CAG33481 DQ896358 ABM87357 EU176413 ABW03864 XM_005259574 XP_005259631 XM_005259575 XP_005259632 XM_005259577 XP_005259634 NM_001193285 NP_001180214 NM_016539 NP_057623
Function	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of R
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889}. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT6 Activity Assay Kit (Fluorometric) - ab156068 from Abcam Category Cellular Assay Prices $464.00 Sizes 100 tests

Human SIRT6 / Sirtuin 6 ELISA Kit (Sandwich ELISA) - LS-F7874 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Mouse SIRT6 / Sirtuin 6 ELISA Kit (Sandwich ELISA) - LS-F8958 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.313-20 ng/ml

NAD-dependent deacetylase sirtuin-6 (SIRT6/SIR2L6), Human, ELISA Kit - CSB-E17018h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

NAD-dependent deacetylase sirtuin-6, SIRT6, Human, ELISA Kit - E2127h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Sirtuin 6 (SIRT6), Human, ELISA Kit - SEE916Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.124ng/mL Range 0.312-20ng/mL

sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , ELISA Kit - MBS705793 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Sirtuin 6, ELISA Kit - MBS088581 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS061264 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS102489 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS102529 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS083361 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS064208 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS098777 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Sirtuin 6 (SIRT6) - SEE916Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.125ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Sirtuin 6 (SIRT6) - SEE916Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NAD-dependent deacetylase sirtuin-6 (SIRT6/SIR2L6) ELISA kit - CSB-E17018h from Cusabio Category ELISA Kit Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

ELISA Kit for Sirtuin 6 (SIRT6) - SEE916Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.125ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SIRT6 / Sirtuin 6 ELISA Kit (Custom ELISA) - LS-F19314 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse SIRT6 / Sirtuin 6 ELISA Kit (Custom ELISA) - LS-F19315 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human Sirtuin 6 (SIRT6) ELISA Kit - EKU07357 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.115 ng/mL Range 0.312-20 ng/mL

Human NAD-dependent deacetylase sirtuin-6 ELISA Kit - abx251450 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Sirtuin 6 ELISA Kit - abx153097 from Abbexa Category ELISA Kit Sensitivity 0.124 ng/ml Range 0.313 ng/ml - 20 ng/ml

Sirtuin 6 (SIRT6), Human, ELISA Kit - DL-SIRT6-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human SIRT6 ELISA Kit - abx572673 from Abbexa Category ELISA Kit Sensitivity 0.124 ng/ml Range 0.313 ng/ml - 20 ng/ml

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