| Gene Symbol |
SIRT6
|
| Entrez Gene |
51548
|
| Alt Symbol |
SIR2L6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 6
|
| Other Description |
NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6|sir2-related protein type 6|sirtuin type 6
|
| Swissprots |
Q6PK99 B2RCD0 Q8N6T7 Q8NCD2 Q9BSI5 Q9UQD1 O75291 Q6IAF5 Q9NRC7 Q9BWP3
|
| Accessions |
AAC34468 AAD15478 CAL00161 EAW69251 EAW69252 EAW69253 EAW69254 EAW69255 EAW69256 EAW69257 EAW69258 EAW69259 Q8N6T7 AF233396 AAF43432 AK074810 BAC11222 AK225567 AK293348 BAG56864 AK299420 BAH13027 AK301247 BAG62814 AK315048 BAG37527 AL365375 BC004218 AAH04218 BC005026 AAH05026 BC028220 AAH28220 CR457200 CAG33481 DQ896358 ABM87357 EU176413 ABW03864 XM_005259574 XP_005259631 XM_005259575 XP_005259632 XM_005259577 XP_005259634 NM_001193285 NP_001180214 NM_016539 NP_057623
|
| Function |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of R
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889}. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
|
| Top Pathways |
Central carbon metabolism in cancer
|
![Western Blot: SIRT6 Overexpression Lysate (Adult Normal) [NBL1-15979] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIRT6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9193_SIRT6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15979-img0002.jpg)