SIRT6

Gene Symbol	SIRT6
Entrez Gene	51548
Alt Symbol	SIR2L6
Species	Human
Gene Type	protein-coding
Description	sirtuin 6
Other Description	NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6|sir2-related protein type 6|sirtuin type 6
Swissprots	Q6PK99 B2RCD0 Q8N6T7 Q8NCD2 Q9BSI5 Q9UQD1 O75291 Q6IAF5 Q9NRC7 Q9BWP3
Accessions	AAC34468 AAD15478 CAL00161 EAW69251 EAW69252 EAW69253 EAW69254 EAW69255 EAW69256 EAW69257 EAW69258 EAW69259 Q8N6T7 AF233396 AAF43432 AK074810 BAC11222 AK225567 AK293348 BAG56864 AK299420 BAH13027 AK301247 BAG62814 AK315048 BAG37527 AL365375 BC004218 AAH04218 BC005026 AAH05026 BC028220 AAH28220 CR457200 CAG33481 DQ896358 ABM87357 EU176413 ABW03864 XM_005259574 XP_005259631 XM_005259575 XP_005259632 XM_005259577 XP_005259634 NM_001193285 NP_001180214 NM_016539 NP_057623
Function	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of R
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889}. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SirT6 siRNA I - 9390 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SIRT6 CRISPR/Cas9 KO Plasmid (h) - sc-412216 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 HDR Plasmid (h) - sc-412216-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 Double Nickase Plasmid (h) - sc-412216-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 Double Nickase Plasmid (h2) - sc-412216-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 CRISPR Activation Plasmid (h) - sc-412216-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 CRISPR Activation Plasmid (h2) - sc-412216-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 Lentiviral Activation Particles (h) - sc-412216-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 Lentiviral Activation Particles (h2) - sc-412216-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT6 siRNA (h) - sc-63028 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIRT6 shRNA Plasmid (h) - sc-63028-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIRT6 shRNA (h) Lentiviral Particles - sc-63028-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIRT6 RNAi - H00051548-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU132901 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19363 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19363 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SIRT6 siRNA (Human) - CRH9825 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIRT6 - MBS8217528 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SIRT6 (NM_016539.2) - SHH407788 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SIRT6(NM_001193285.1) - SHR226590 from Creative biogene Category siRNA Species Reactivities Human

Human SIRT6 siRNA - orb270327 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIRT6 shRNA Plasmid (Human) - CHH9825 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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