SIRT6

Gene Symbol SIRT6
Entrez Gene 51548
Alt Symbol SIR2L6
Species Human
Gene Type protein-coding
Description sirtuin 6
Other Description NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6|sir2-related protein type 6|sirtuin type 6
Swissprots Q6PK99 B2RCD0 Q8N6T7 Q8NCD2 Q9BSI5 Q9UQD1 O75291 Q6IAF5 Q9NRC7 Q9BWP3
Accessions AAC34468 AAD15478 CAL00161 EAW69251 EAW69252 EAW69253 EAW69254 EAW69255 EAW69256 EAW69257 EAW69258 EAW69259 Q8N6T7 AF233396 AAF43432 AK074810 BAC11222 AK225567 AK293348 BAG56864 AK299420 BAH13027 AK301247 BAG62814 AK315048 BAG37527 AL365375 BC004218 AAH04218 BC005026 AAH05026 BC028220 AAH28220 CR457200 CAG33481 DQ896358 ABM87357 EU176413 ABW03864 XM_005259574 XP_005259631 XM_005259575 XP_005259632 XM_005259577 XP_005259634 NM_001193285 NP_001180214 NM_016539 NP_057623
Function NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of R
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889}. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
Top Pathways Central carbon metabolism in cancer

SirT6 (D8D12) Rabbit mAb - 12486 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8D12
Western blot analysis of extracts from various cell lines using SirT6 (D8D12) Rabbit mAb.

SirT6 Antibody - 2590 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of various cell types using SirT6 Antibody.

SirT6 (D10A4) Rabbit mAb - 8771 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A4
Western blot analysis of extracts from HCT 116, 293, and K-562 cells using SirT6 (D10A4) Rabbit mAb.

Anti-SIRT6 antibody - ab88494 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT6 antibody (ab88494) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µg

Anti-SIRT6 antibody - ab62738 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 antibody - ab105391 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Lane 1 : Anti-SIRT6 antibody (ab105391) at 0.5 µg/mlLane 2 : Anti-SIRT6 antibody (ab105391) at 1 µg/mlLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLysates/proteins at 15 µg per lane.

Anti-SIRT6 antibody - ab118487 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT6 antibody (ab118487) + U2OS cell lysate

Anti-SIRT6 antibody - ab105041 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT6 antibody (ab105041) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 7 : Raji (Human Burkitt's lymphoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SIRT6 antibody - ab116524 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT6 antibody (ab116524) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-SIRT6 antibody - ab172494 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SIRT6 antibody (ab172494) at 1 µg/mlLane 1 : SIRT6-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SIRT6 antibody [1G3] - ab119007 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G3
All lanes : Anti-SIRT6 antibody [1G3] (ab119007) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SIRT6 cDNALysates/proteins at 5 µg per lane.

Anti-SIRT6 antibody [EPR5079(N)] - ab176345 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5079(N)
All lanes : Anti-SIRT6 antibody [EPR5079(N)] (ab176345) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : 293T cell lysateLane 4 : HepG2 cell lysateLane 5 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-SIRT6 antibody - C-terminal - ab135566 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT6 antibody - C-terminal (ab135566) at 1/100 dilution + Mouse stomach tissue lysate at 35 µg

Anti-SIRT6 antibody - ChIP Grade - ab62739 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab62739 staining SIRT6 in mouse pancreas tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 5% serum for 1 hour at 25°C; antigen retrieval was by heat mediation in a sodium citrate buffer. Samples were incubated with primary antibody (1/200) for 16 hours at 4°C. A HRP-conjugated donkey anti-rabbit IgG polyclonal (1/500) was used as the secondary antibody.See Abreview

Anti-SIRT6 / Sirtuin 6 Antibody (aa50-100) - LS-C289188 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (C-Terminus, FITC) - LS-C282736 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (C-Terminus, PE) - LS-C282738 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa305-355) - LS-C289190 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa1-355, Biotin) - LS-C298044 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa1-334, Biotin) - LS-C299643 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa88-288, Biotin) - LS-C300758 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa1-355, FITC) - LS-C301820 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa305-320) IHC-plus™ - LS-B900 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT6 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B900 concentration 10 ug/ml.

Anti-SIRT6 / Sirtuin 6 Antibody (aa1-334, FITC) - LS-C301976 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT6 / Sirtuin 6 Antibody (aa88-288, FITC) - LS-C303683 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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