GABARAP

Gene Symbol GABARAP
Entrez Gene 11337
Alt Symbol ATG8A, GABARAP-a, MM46
Species Human
Gene Type protein-coding
Description GABA(A) receptor-associated protein
Other Description gamma-aminobutyric acid receptor-associated protein
Swissprots O95166
Accessions EAW90234 EAW90238 O95166 AB030711 BAB21549 AF044671 AAD02337 AF067171 AAD32455 AF161586 AAD47641 AF183425 AAG09694 AK098634 AK312205 BAG35138 BC106748 AAI06749 BC106749 AAI06750 CR457043 CAG33324 CR542235 CAG47031 JN663880 AEZ06293 U65413 NM_007278 NP_009209
Function Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:15977068}.
Subcellular Location Endomembrane system {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.
Tissue Specificity Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:9892355}.
Top Pathways GABAergic synapse, Regulation of autophagy

GABARAP (E1J4E) Rabbit mAb - 13733 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1J4E
Western blot analysis of A172 and C2C12 cells, untreated (-) or chloroquine-treated (50 μM, overnight; +), using GABARAP (E1J4E) Rabbit mAb.

GABARAP Antibody - 11876 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

GABARAP (E-8) - sc-377300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GABARAP (E-8): sc-377300. Western blot analysis of GABARAP expression in HeLa (A) and MIA PaCa-2 (B) whole cell lysates.

GABARAP (FL-117) - sc-28938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GABARAP (FL-117): sc-28938. Western blot analysis of human recombinant GABARAP fusion protein.

GABARAP (C-19) - sc-9190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABARAP (C-19): sc-9190. Western blot analysis of human recombinant GABARAP fusion protein.

GABARAP (N-14) - sc-9189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABARAP (N-14): sc-9189. Western blot analysis of GABARAP expression in HeLa (A) and SH-SY5Y (B) whole cell lysates.

Anti-GABARAP antibody - ab62471 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab62471 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab62471, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-GABARAP antibody - ab62114 from Abcam

Host Sheep
Clonality Polyclonal

Anti-GABARAP antibody - ab1398 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GABARAP antibody [EPR4805] - ab109364 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4805
All lanes : Anti-GABARAP antibody [EPR4805] (ab109364) at 1/1000 dilutionLane 1 : Fetal kidney lysateLane 2 : SH-SY5Y cell lysateLane 3 : HepG2 cell lysateLane 4 : Fetal brain lysateLysates/proteins at 10 µg per lane.

Anti-GABARAP antibody [EPR4806] - ab109299 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4806
All lanes : Anti-GABARAP antibody [EPR4806] (ab109299) at 1/1000 dilutionLane 1 : Fetal brain tissue lysate at 10 µgLane 2 : SH-SY5Y cell lysate at 10 µgLane 3 : Flag-GABARAP

Anti-GABARAP Antibody (Internal, clone EPR4806) - LS-C138244 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4806
IHC of paraffin-embedded human brain tissue using anti-GABARAP antibody.

Anti-GABARAP Antibody (N-Terminus) - LS-C201091 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of GABARAP in human brain tissue with GABARAP antibody at 20 ug/ml.

Anti-GABARAP Antibody (N-Terminus) IHC-plus™ - LS-B283 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GABARAP antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B283 concentration 5 ug/ml.

Anti-GABARAP Antibody (aa1-30) - LS-C166311 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with Autophagy GABARAP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-GABARAP Antibody - LS-C334171 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using GABARAP antibody. Blue: DAPI for nuclear staining.

Anti-GABARAP Antibody (N-Terminus) - LS-C7025 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (N-Terminus) - LS-C83572 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (aa15-31) - LS-C40598 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody - LS-C94148 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-GABARAP Antibody (N-Terminus) - LS-C63377 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (Biotin) - LS-C180678 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (DY650) - LS-C180679 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (DY488) - LS-C180680 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAP Antibody (DY550) - LS-C180681 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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