| Gene Symbol |
GABARAP
|
| Entrez Gene |
11337
|
| Alt Symbol |
ATG8A, GABARAP-a, MM46
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GABA(A) receptor-associated protein
|
| Other Description |
gamma-aminobutyric acid receptor-associated protein
|
| Swissprots |
O95166
|
| Accessions |
EAW90234 EAW90238 O95166 AB030711 BAB21549 AF044671 AAD02337 AF067171 AAD32455 AF161586 AAD47641 AF183425 AAG09694 AK098634 AK312205 BAG35138 BC106748 AAI06749 BC106749 AAI06750 CR457043 CAG33324 CR542235 CAG47031 JN663880 AEZ06293 U65413 NM_007278 NP_009209
|
| Function |
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:15977068}.
|
| Subcellular Location |
Endomembrane system {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:9892355}.
|
| Top Pathways |
GABAergic synapse, Regulation of autophagy
|