Gene Symbol | GABARAP |
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Entrez Gene | 11337 |
Alt Symbol | ATG8A, GABARAP-a, MM46 |
Species | Human |
Gene Type | protein-coding |
Description | GABA(A) receptor-associated protein |
Other Description | gamma-aminobutyric acid receptor-associated protein |
Swissprots | O95166 |
Accessions | EAW90234 EAW90238 O95166 AB030711 BAB21549 AF044671 AAD02337 AF067171 AAD32455 AF161586 AAD47641 AF183425 AAG09694 AK098634 AK312205 BAG35138 BC106748 AAI06749 BC106749 AAI06750 CR457043 CAG33324 CR542235 CAG47031 JN663880 AEZ06293 U65413 NM_007278 NP_009209 |
Function | Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:15977068}. |
Subcellular Location | Endomembrane system {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}. |
Tissue Specificity | Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:9892355}. |
Top Pathways | GABAergic synapse, Regulation of autophagy |
Human GABARAP full length protein - ab151871 from Abcam
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Human GABARAP full length protein - ab191929 from Abcam
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Human GABARAP full length protein - ab93455 from Abcam
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Human GABARAP full length protein - ab116475 from Abcam
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GABARAP Antibody Blocking Peptide - LS-E5684 from LifeSpan Bioscience
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GABARAP Antibody Blocking Peptide - LS-E18455 from LifeSpan Bioscience
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GABARAP Antibody Blocking Peptide - LS-E18456 from LifeSpan Bioscience
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GABARAP Antibody Blocking Peptide - LS-E31442 from LifeSpan Bioscience
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GABARAP Antibody Blocking Peptide - LS-E21555 from LifeSpan Bioscience
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GABARAP Recombinant Protein - H00011337-P01 from Novus Biologicals
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GABARAP Partial Recombinant Protein - H00011337-Q01 from Novus Biologicals
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Recombinant Human GABARAP Protein - NBP1-37084 from Novus Biologicals
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Recombinant Human HA-GABARAP/Apg8p1 Vinyl Sulfone, CF - UL-441-025 from R&D Systems
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Recombinant Human His6-GABARAP/Apg8p1, CF - UL-410-500 from R&D Systems
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Recombinant Human His6-GABARAP/Apg8p1 Biotin, CF - UL-412-050 from R&D Systems
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Recombinant Human GABARAP Agarose, CF - UL-415-500 from R&D Systems
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Recombinant Human His6-GABARAP Fluorescein, CF - UL-414-050 from R&D Systems
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Recombinant Human His6-GABARAP Rhodamine, CF - UL-416-050 from R&D Systems
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GABARAP Protein (OPPA01946) - OPPA01946 from Aviva Systems Biology
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GABARAP (MBP Tag) protein - orb171540 from Biorbyt
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Human GABARAP (N-His tag) protein - orb180276 from Biorbyt
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Human GABARAP protein - orb245244 from Biorbyt
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Human Gamma-Aminobutyric Acid Receptor-Associated protein - orb81131 from Biorbyt
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Human GABARAP protein - orb49396 from Biorbyt
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GABARAP Blocking Peptide - 33R-3983 from Fitzgerald
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