| Gene Symbol |
PLGRKT
|
| Entrez Gene |
55848
|
| Alt Symbol |
AD025, C9orf46, MDS030, PLG-RKT, Plg-R(KT)
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plasminogen receptor, C-terminal lysine transmembrane protein
|
| Other Description |
5033414D02Rik|plasminogen receptor (KT)|plasminogen receptor with a C-terminal lysine|transmembrane protein C9orf46
|
| Swissprots |
Q9HBL7 Q9NZ44 B2R6W0
|
| Accessions |
CAE89441 EAW58764 EAW58765 EAW58766 Q9HBL7 AA919015 AF220050 AAF67643 AF225420 AAG09722 AK027594 BAB55219 AK312736 BAG35607 BC008212 AAH08212 BC036853 BM693747 HQ448307 ADQ32787 XM_005251510 XP_005251567 XM_005251512 XP_005251569 XM_011517960 XP_011516262 NM_018465 NP_060935
|
| Function |
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269|PubMed:21940822}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21940822}; Multi-pass membrane protein {ECO:0000269|PubMed:21940822}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla. {ECO:0000269|PubMed:21795689, ECO:0000269|PubMed:21940822}.
|