Gene Symbol | PLGRKT |
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Entrez Gene | 55848 |
Alt Symbol | AD025, C9orf46, MDS030, PLG-RKT, Plg-R(KT) |
Species | Human |
Gene Type | protein-coding |
Description | plasminogen receptor, C-terminal lysine transmembrane protein |
Other Description | 5033414D02Rik|plasminogen receptor (KT)|plasminogen receptor with a C-terminal lysine|transmembrane protein C9orf46 |
Swissprots | Q9HBL7 Q9NZ44 B2R6W0 |
Accessions | CAE89441 EAW58764 EAW58765 EAW58766 Q9HBL7 AA919015 AF220050 AAF67643 AF225420 AAG09722 AK027594 BAB55219 AK312736 BAG35607 BC008212 AAH08212 BC036853 BM693747 HQ448307 ADQ32787 XM_005251510 XP_005251567 XM_005251512 XP_005251569 XM_011517960 XP_011516262 NM_018465 NP_060935 |
Function | Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269|PubMed:21940822}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21940822}; Multi-pass membrane protein {ECO:0000269|PubMed:21940822}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}. |
Tissue Specificity | Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla. {ECO:0000269|PubMed:21795689, ECO:0000269|PubMed:21940822}. |
C9orf46 (Q-12) - sc-167365 from Santa Cruz Biotechnology
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Anti-C9ORF46 antibody - ab82868 from Abcam
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Anti-C9ORF46 antibody - ab81148 from Abcam
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Anti-PLGRKT / C9orf46 Antibody (C-Terminus) - LS-C81358 from LifeSpan Bioscience
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Anti-PLGRKT / C9orf46 Antibody (aa72-121) - LS-C81357 from LifeSpan Bioscience
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C9orf46 Antibody - NBP1-89253 from Novus Biologicals
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C9orf46 Antibody - NBP1-59462 from Novus Biologicals
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C9orf46 Antibody - NBP1-89254 from Novus Biologicals
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C9ORF46 Polyclonal Antibody - bs-9489R from Bioss
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Anti-C9ORF46 antibody produced in rabbit - AV49315 from Sigma-Aldrich
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Anti-C9ORF46 antibody produced in rabbit - SAB2100325 from Sigma-Aldrich
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Anti-PLGRKT antibody produced in rabbit - HPA008214 from Sigma-Aldrich
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Anti-PLGRKT antibody produced in rabbit - HPA011144 from Sigma-Aldrich
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C9orf46 antibody - middle region (ARP49314_P050) - ARP49314_P050 from Aviva Systems Biology
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C9orf46 antibody - middle region (ARP49315_P050) - ARP49315_P050 from Aviva Systems Biology
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C9ORF46 antibody, Internal - GTX46092 from GeneTex
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C9ORF46 antibody, Internal - GTX46093 from GeneTex
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C9ORF46 antibody - 70R-6362 from Fitzgerald
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C9ORF46 antibody - orb2859 from Biorbyt
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C9ORF46 antibody - 70R-6739 from Fitzgerald
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C9orf46 Antibody - 26-390 from ProSci
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C9orf46 Antibody - 26-391 from ProSci
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C9orf46 antibody - 26101-1-AP from Proteintech Group
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C9orf46 Antibody - GWB-MR465F from Genway Biotech
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C9orf46 Antibody - GWB-MR466G from Genway Biotech
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