Gene Symbol | PLGRKT |
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Entrez Gene | 55848 |
Alt Symbol | AD025, C9orf46, MDS030, PLG-RKT, Plg-R(KT) |
Species | Human |
Gene Type | protein-coding |
Description | plasminogen receptor, C-terminal lysine transmembrane protein |
Other Description | 5033414D02Rik|plasminogen receptor (KT)|plasminogen receptor with a C-terminal lysine|transmembrane protein C9orf46 |
Swissprots | Q9HBL7 Q9NZ44 B2R6W0 |
Accessions | CAE89441 EAW58764 EAW58765 EAW58766 Q9HBL7 AA919015 AF220050 AAF67643 AF225420 AAG09722 AK027594 BAB55219 AK312736 BAG35607 BC008212 AAH08212 BC036853 BM693747 HQ448307 ADQ32787 XM_005251510 XP_005251567 XM_005251512 XP_005251569 XM_011517960 XP_011516262 NM_018465 NP_060935 |
Function | Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269|PubMed:21940822}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21940822}; Multi-pass membrane protein {ECO:0000269|PubMed:21940822}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. {ECO:0000250}. |
Tissue Specificity | Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla. {ECO:0000269|PubMed:21795689, ECO:0000269|PubMed:21940822}. |
PLGRKT / C9orf46 Antibody Blocking Peptide - LS-E17808 from LifeSpan Bioscience
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PLGRKT / C9orf46 Antibody Blocking Peptide - LS-E17809 from LifeSpan Bioscience
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C9orf46-Antibody-C-term-Blocking-Peptide - BP16198b from Abgent, a WuXi AppTec company
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C9ORF46 Blocking Peptide - 33R-3611 from Fitzgerald
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C9ORF46 Blocking Peptide - 33R-1270 from Fitzgerald
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C9orf46 fusion protein - Ag23410 from Proteintech Group
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C9orf46 Recombinant Protein Antigen - NBP1-89254PEP from Novus Biologicals
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C9orf46 Protein - NBP1-89253PEP from Novus Biologicals
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PLGRKT Peptide, Human - M34GP11956H from Creative Peptides
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PLGRKT Blocking Peptide - CBP7500 from Cohesion Biosciences
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Plasminogen receptor (KT) (C9orf46), Recombinant Protein - MBS7010620 from MyBioSource
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PLGRKT peptide - orb382405 from Biorbyt
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