| Gene Symbol |
Noto
|
| Entrez Gene |
384452
|
| Alt Symbol |
Flh, MmNot, Not, tc
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
notochord homolog (Xenopus laevis)
|
| Other Description |
Not homeodomain protein|floating head homolog|homeobox protein notochord|truncate
|
| Swissprots |
Q5TIS6
|
| Accessions |
Q5TIS6 AJ862873 CAI05851 AJ862874 CAI05852 AJ862875 CAI05853 AK135886 BAE22716 BC139154 AAI39155 BC139155 AAI39156 XM_006506356 XP_006506419 NM_001007472 NP_001007473
|
| Function |
Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. {ECO:0000269|PubMed:15231714, ECO:0000269|PubMed:17884984, ECO:0000269|PubMed:18061569}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|