Gene Symbol | Noto |
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Entrez Gene | 384452 |
Alt Symbol | Flh, MmNot, Not, tc |
Species | Mouse |
Gene Type | protein-coding |
Description | notochord homolog (Xenopus laevis) |
Other Description | Not homeodomain protein|floating head homolog|homeobox protein notochord|truncate |
Swissprots | Q5TIS6 |
Accessions | Q5TIS6 AJ862873 CAI05851 AJ862874 CAI05852 AJ862875 CAI05853 AK135886 BAE22716 BC139154 AAI39155 BC139155 AAI39156 XM_006506356 XP_006506419 NM_001007472 NP_001007473 |
Function | Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. {ECO:0000269|PubMed:15231714, ECO:0000269|PubMed:17884984, ECO:0000269|PubMed:18061569}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
Recombinant Mouse Homeobox protein notochord(Noto) - CSB-YP722584MO CSB-EP722584MO CSB-BP722584MO CSB-MP722584MO from Cusabio
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Recombinant Mouse NOTO Protein - NOTO-10793M from Creative Biomart
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Mouse-Noto-Blocking-Peptide-C-term - BP21141a from Abgent, a WuXi AppTec company
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Homeobox protein notochord (Noto), Recombinant Protein - MBS1384825 from MyBioSource
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