| Gene Symbol |
PHAX
|
| Entrez Gene |
51808
|
| Alt Symbol |
RNUXA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphorylated adaptor for RNA export
|
| Other Description |
RNA U small nuclear RNA export adapter protein|RNA U, small nuclear RNA export adapter (phosphorylation regulated)|RNA U, small nuclear RNA export adaptor (phosphorylation regulated)|phosphorylated adapter RNA export protein
|
| Swissprots |
Q9H8W1 Q9H814
|
| Accessions |
EAW48850 Q9H814 AF086448 AK023255 BAB14489 AK024065 BAB14809 AK225464 AK298497 BAG60704 BC021161 AAH21161 CR457305 CAG33586 DQ893213 ABM84139 DQ896542 ABM87541 N44678 NM_032177 NP_115553
|
| Function |
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner (By similarity). Plays also a rol
|
| Subcellular Location |
Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.
|
| Top Pathways |
RNA transport
|
![Western Blot: PHAX Overexpression Lysate (Adult Normal) [NBL1-15472] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PHAX.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9391_PHAX%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15472-img0002.jpg)