| Gene Symbol | PHAX |
|---|---|
| Entrez Gene | 51808 |
| Alt Symbol | RNUXA |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphorylated adaptor for RNA export |
| Other Description | RNA U small nuclear RNA export adapter protein|RNA U, small nuclear RNA export adapter (phosphorylation regulated)|RNA U, small nuclear RNA export adaptor (phosphorylation regulated)|phosphorylated adapter RNA export protein |
| Swissprots | Q9H8W1 Q9H814 |
| Accessions | EAW48850 Q9H814 AF086448 AK023255 BAB14489 AK024065 BAB14809 AK225464 AK298497 BAG60704 BC021161 AAH21161 CR457305 CAG33586 DQ893213 ABM84139 DQ896542 ABM87541 N44678 NM_032177 NP_115553 |
| Function | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner (By similarity). Plays also a rol |
| Subcellular Location | Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. |
| Top Pathways | RNA transport |
PHAX CRISPR/Cas9 KO Plasmid (h) - sc-407796 from Santa Cruz Biotechnology
|
||||||||
PHAX HDR Plasmid (h) - sc-407796-HDR from Santa Cruz Biotechnology
|
||||||||
PHAX Double Nickase Plasmid (h) - sc-407796-NIC from Santa Cruz Biotechnology
|
||||||||
PHAX Double Nickase Plasmid (h2) - sc-407796-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PHAX CRISPR Activation Plasmid (h) - sc-407796-ACT from Santa Cruz Biotechnology
|
||||||||
PHAX CRISPR Activation Plasmid (h2) - sc-407796-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PHAX Lentiviral Activation Particles (h) - sc-407796-LAC from Santa Cruz Biotechnology
|
||||||||
PHAX Lentiviral Activation Particles (h2) - sc-407796-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PHAX siRNA (h) - sc-106785 from Santa Cruz Biotechnology
|
||||||||
PHAX shRNA Plasmid (h) - sc-106785-SH from Santa Cruz Biotechnology
|
||||||||
PHAX shRNA (h) Lentiviral Particles - sc-106785-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU031221 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN16708 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16708 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04888 from Sigma-Aldrich
|
||||||||
PHAX siRNA (Human) - CRH9953 from Cohesion Biosciences
|
||||||||
shRNA set against Human PHAX (NM_032177.3) - SHH374512 from Creative biogene
|
||||||||
Human PHAX siRNA - orb270455 from Biorbyt
|
||||||||
PHAX shRNA Plasmid (Human) - CHH9953 from Cohesion Biosciences
|
||||||||
PHAX miRNA 3'UTR clone - MiUTR3H-07211 from Creative biogene
|