PHAX

Gene Symbol	PHAX
Entrez Gene	51808
Alt Symbol	RNUXA
Species	Human
Gene Type	protein-coding
Description	phosphorylated adaptor for RNA export
Other Description	RNA U small nuclear RNA export adapter protein|RNA U, small nuclear RNA export adapter (phosphorylation regulated)|RNA U, small nuclear RNA export adaptor (phosphorylation regulated)|phosphorylated adapter RNA export protein
Swissprots	Q9H8W1 Q9H814
Accessions	EAW48850 Q9H814 AF086448 AK023255 BAB14489 AK024065 BAB14809 AK225464 AK298497 BAG60704 BC021161 AAH21161 CR457305 CAG33586 DQ893213 ABM84139 DQ896542 ABM87541 N44678 NM_032177 NP_115553
Function	A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner (By similarity). Plays also a rol
Subcellular Location	Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHAX full length protein - ab162674 from Abcam Category Protein Source Wheat germ Species Human

PHAX Antibody Blocking Peptide - LS-E1978 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHAX Antibody Blocking Peptide - LS-E23835 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHAX Antibody Blocking Peptide - LS-E23836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHAX Recombinant Protein - H00051808-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PHAX-Antibody-C-term-Blocking-peptide - BP12834b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHAX / RNUXA - H00051808-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PHAX / RNUXA - H00051808-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PHAX fusion protein - Ag9047 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PHAX fusion protein - ag9602 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PHAX, His-tagged - PHAX-1673H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PHAX - PHAX-729H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Phosphorylated adapter RNA export protein(PHAX) - CSB-YP863999HU CSB-EP863999HU CSB-BP863999HU CSB-MP863999HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Phosphorylated adapter RNA export protein (PHAX), Recombinant Protein - MBS1331429 from MyBioSource Category Protein Prices $1,165.00, $1,165.00, $1,395.00, $1,395.00, $1,865.00, $1,865.00, $2,330.00, $2,330.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PHAX Peptide, Human - M34GP11677H from Creative Peptides Category Peptide Source Synthetic. Species Human

PHAX Recombinant Protein Antigen - NBP2-48821PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

PHAX Recombinant Protein Antigen - NBP2-55912PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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