PHAX

Gene Symbol PHAX
Entrez Gene 51808
Alt Symbol RNUXA
Species Human
Gene Type protein-coding
Description phosphorylated adaptor for RNA export
Other Description RNA U small nuclear RNA export adapter protein|RNA U, small nuclear RNA export adapter (phosphorylation regulated)|RNA U, small nuclear RNA export adaptor (phosphorylation regulated)|phosphorylated adapter RNA export protein
Swissprots Q9H8W1 Q9H814
Accessions EAW48850 Q9H814 AF086448 AK023255 BAB14489 AK024065 BAB14809 AK225464 AK298497 BAG60704 BC021161 AAH21161 CR457305 CAG33586 DQ893213 ABM84139 DQ896542 ABM87541 N44678 NM_032177 NP_115553
Function A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner (By similarity). Plays also a rol
Subcellular Location Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.
Top Pathways RNA transport

PHAX (F-1) - sc-398147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PHAX (F-1): sc-398147. Western blot analysis of PHAX expression in HeLa nuclear extract (A), Hep G2 whole cell lysate (B) and human cerebellum tissue extract (C).

PHAX (H-75) - sc-368882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PHAX (M-19) - sc-11704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PHAX (M-19): sc-11704. Western blot analysis of PHAX expression in mouse cerebellum tissue extract.

Anti-PHAX antibody - ab157096 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PHAX antibody (ab157096) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PHAX antibody - ab110525 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PHAX antibody (ab110525) at 1/500 dilutionLane 1 : HT-29 cell lysateLane 2 : HT-29 cell lysate with blocking peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-PHAX antibody - ab133821 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PHAX antibody (ab133821) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-PHAX antibody - ab154615 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PHAX antibody (ab154615) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-PHAX antibody - C-terminal - ab171321 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PHAX antibody - C-terminal (ab171321) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-PHAX Antibody (aa297-326) - LS-C163560 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PHAX Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PHAX Antibody (aa344-394) - LS-C290563 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PHAX by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-PHAX antibody used for IP at 6 ug/mg lysate. PHAX was also immunoprecipitated by rabbit anti-PHAX antibody BL14107. For blotting immunoprecipitated PHAX, was used at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-PHAX Antibody (aa297-326, AP) - LS-C226958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa297-326, APC) - LS-C226959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa297-326, Biotin) - LS-C226960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa297-326, FITC) - LS-C226961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa297-326, Azide-free, HRP) - LS-C226962 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa297-326, PE) - LS-C226963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa304-334) - LS-C323977 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PHAX Antibody (aa306-355) - LS-C151989 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PHAX antibody Western Blot of HepG2.

Anti-PHAX Antibody (aa153-202) - LS-C186773 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Liver. PHAX antibody dilution 1.0 ug/ml.

Anti-PHAX Antibody (aa141-190) - LS-C120347 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HT-29 cells, using RNUXA Antibody. The lane on the right is treated with the synthesized peptide.

PHAX Antibody - NBP2-22268 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PHAX Antibody [NBP2-22268] - Whole cell lysate from mouse NIH3T3 (15 and 50 ug) cells. NBP2-22268 used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

PHAX Antibody - NBP2-19792 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PHAX Antibody [NBP2-19792] - Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE gel, diluted at 1:500.

PHAX Antibody - NBP1-56207 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PHAX Antibody [NBP1-56207] - Analysis of extracts from HT-29 cells, using PHAX Antibody. The lane on the right is treated with the synthesized peptide.

Anti-RNUXA antibody produced in rabbit - SAB4502172 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RNUXA: <B>Cat. No. SAB4502172</B>: Immunoblotting analysis of extracts from HT-29 cells, using Anti-RNUXA antibody. The lane on the left was treated with the Anti-RNUXA antibody. The lane on the right (negative control) was treated with both Anti-RNUXA antibody and the synthesized immunogen peptide.

Anti-PHAX antibody produced in rabbit - SAB2701593 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PHAX: <B>Cat. No. SAB2701593</B>: Western Blot analysis of PHAX in extracts from <B>Lanes</B><BR/>A. 293T using <B>Cat. No. SAB2701593</B> at a 1:500 dilution.
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