| Gene Symbol |
UBE4B
|
| Entrez Gene |
10277
|
| Alt Symbol |
E4, HDNB1, UBOX3, UFD2, UFD2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitination factor E4B
|
| Other Description |
UFD2A-III/UBE4B-III splice isoform|homologous to yeast UFD2|homozygously deleted in neuroblastoma 1|homozygously deleted in neuroblastoma-1|ubiquitin conjugation factor E4 B|ubiquitin fusion degradation protein 2|ubiquitin-fusion degradation protein 2|ubiquitination factor E4B (UFD2 homolog, yeast)|ubiquitination factor E4B (homologous to yeast UFD2)
|
| Swissprots |
Q96QD4 O75169 Q5SZ12 O95338 Q9BYI7 A8K8S9 O95155 G0ZJH6 Q5SZ16
|
| Accessions |
EAW71639 EAW71640 O95155 AB014584 BAA31659 AB028839 BAB40446 AF043117 AAD02233 AF091093 AAC72962 AF331520 AAK69622 AK023654 AK292444 BAF85133 AK304484 BAG65294 BC047890 BC093696 AAH93696 BC143458 BC143460 BQ001243 DA476510 JF289274 AEK06331 XM_005263422 XP_005263479 XM_011540488 XP_011538790 XM_011540489 XP_011538791 XM_011540490 XP_011538792 XR_946516 NM_001105562 NP_001099032 NM_006048 NP_006039
|
| Function |
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q9ES00}. Nucleus {ECO:0000250|UniProtKB:Q9ES00}.
|
| Tissue Specificity |
Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen. {ECO:0000269|PubMed:11802788}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|