Gene Symbol | SNRPD3 |
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Entrez Gene | 6634 |
Alt Symbol | SMD3, Sm-D3 |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein D3 polypeptide 18kDa |
Other Description | small nuclear ribonucleoprotein Sm D3|snRNP core protein D3 |
Swissprots | B5BU13 B4DJP7 P62318 |
Accessions | EAW59670 P62318 AB451249 BAG70063 AB451373 BAG70187 AK296173 BAG58909 BC000457 AAH00457 BC003150 AAH03150 BC034447 BF344644 BM928709 BP202359 BY993733 CN286602 CR456583 CAG30469 CU013182 CAK54613 CU013470 CAK54912 U15009 AAA57034 NM_001278656 NP_001265585 NM_004175 NP_004166 NR_103819 |
Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:18984161}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
Top Pathways | Systemic lupus erythematosus, Spliceosome |
Sm D3 CRISPR/Cas9 KO Plasmid (h) - sc-405302 from Santa Cruz Biotechnology
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Sm D3 HDR Plasmid (h) - sc-405302-HDR from Santa Cruz Biotechnology
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Sm D3 Double Nickase Plasmid (h) - sc-405302-NIC from Santa Cruz Biotechnology
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Sm D3 Double Nickase Plasmid (h2) - sc-405302-NIC-2 from Santa Cruz Biotechnology
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Sm D3 CRISPR Activation Plasmid (h) - sc-405302-ACT from Santa Cruz Biotechnology
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Sm D3 CRISPR Activation Plasmid (h2) - sc-405302-ACT-2 from Santa Cruz Biotechnology
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Sm D3 Lentiviral Activation Particles (h) - sc-405302-LAC from Santa Cruz Biotechnology
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Sm D3 Lentiviral Activation Particles (h2) - sc-405302-LAC-2 from Santa Cruz Biotechnology
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Sm D3 siRNA (h) - sc-38327 from Santa Cruz Biotechnology
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Sm D3 shRNA Plasmid (h) - sc-38327-SH from Santa Cruz Biotechnology
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Sm D3 shRNA (h) Lentiviral Particles - sc-38327-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU049811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20273 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20273 from Sigma-Aldrich
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SNRPD3 siRNA (Human) - CRH4516 from Cohesion Biosciences
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SNRPD3 - MBS8226484 from MyBioSource
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shRNA set against Human SNRPD3 (NM_004175.3) - SHH414388 from Creative biogene
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shRNA set against Human SNRPD3(NM_004175.3) - SHL022314 from Creative biogene
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Human SNRPD3 siRNA - orb265018 from Biorbyt
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SNRPD3 shRNA Plasmid (Human) - CHH4516 from Cohesion Biosciences
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SNRPD3 miRNA 3'UTR clone - MiUTR1H-09700 from Creative biogene
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