| Gene Symbol |
TNFRSF11A
|
| Entrez Gene |
8792
|
| Alt Symbol |
CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
|
| Other Description |
Paget disease of bone 2|loss of heterozygosity, 18, chromosomal region 1|osteoclast differentiation factor receptor|receptor activator of NF-KB|receptor activator of nuclear factor-kappa B|tumor necrosis factor receptor superfamily member 11A
|
| Swissprots |
I4EC36 I7JE63 I4EC38 N0GVH0 Q59EP9 I4EC39 Q9Y6Q6
|
| Accessions |
CAX21650 CAX24318 EAW63124 Q9Y6Q6 AB209762 BAD92999 AF018253 AAB86809 AF086403 BC152906 AAI52907 DA403964 HE647782 CCF23032 HE649916 CCF55033 HE649917 CCF55034 HE659518 CCF77738 HF584702 CCQ44072 XM_011526244 XP_011524546 XM_011526245 XP_011524547 XR_935263 NM_001270949 NP_001257878 NM_001270950 NP_001257879 NM_001270951 NP_001257880 NM_001278268 NP_001265197 NM_003839 NP_003830
|
| Function |
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000269|PubMed:23664977}; Single-pass type I membrane protein {ECO:0000269|PubMed:23664977}.
|
| Tissue Specificity |
Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway
|