TNFRSF11A

Gene Symbol TNFRSF11A
Entrez Gene 8792
Alt Symbol CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Other Description Paget disease of bone 2|loss of heterozygosity, 18, chromosomal region 1|osteoclast differentiation factor receptor|receptor activator of NF-KB|receptor activator of nuclear factor-kappa B|tumor necrosis factor receptor superfamily member 11A
Swissprots I4EC36 I7JE63 I4EC38 N0GVH0 Q59EP9 I4EC39 Q9Y6Q6
Accessions CAX21650 CAX24318 EAW63124 Q9Y6Q6 AB209762 BAD92999 AF018253 AAB86809 AF086403 BC152906 AAI52907 DA403964 HE647782 CCF23032 HE649916 CCF55033 HE649917 CCF55034 HE659518 CCF77738 HF584702 CCQ44072 XM_011526244 XP_011524546 XM_011526245 XP_011524547 XR_935263 NM_001270949 NP_001257878 NM_001270950 NP_001257879 NM_001270951 NP_001257880 NM_001278268 NP_001265197 NM_003839 NP_003830
Function Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}.
Subcellular Location Isoform 1: Cell membrane {ECO:0000269|PubMed:23664977}; Single-pass type I membrane protein {ECO:0000269|PubMed:23664977}.
Tissue Specificity Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Top Pathways Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway

RANK Antibody - 4845 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 (human), KNRK (rat) and C2C12 (mouse) cell lines, using RANK Antibody.

RANK (H-7) - sc-374360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RANK (H-7): sc-374360. Western blot analysis of RANK expression in non-transfected: sc-117752 (A) and mouse RANK transfected: sc-122962 (B) 293T whole cell lysates.

RANK (B-8) - sc-390655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RANK (B-8): sc-390655. Western blot analysis of RANK expression in non-transfected: sc-117752 (A) and mouse RANK transfected: sc-122962 (B) 293T whole cell lysates.

RANK (H-300) - sc-9072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RANK (H-300): sc-9072. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing membrane and cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

RANK (D-20) - sc-34249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RANK (D-20): sc-34249. Western blot analysis of RANK expression in non-transfected 293T: sc-117752 (A), mouse RANK transfected 293T: sc-122962 (B) and Hep G2 (C) whole cell lysates.

RANK (M-20) - sc-7624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RANK (M-20): sc-7624. Western blot analysis of RANK expression in non-transfected: sc-117752 (A) and mouse RANK transfected: sc-122962 (B) 293T whole cell lysates.

RANK (N-20) - sc-7626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RANK (N-20): sc-7626. Western blot analysis of RANK expression in c4 whole cell lysate.

RANK (C-20) - sc-7625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RANK (C-20): sc-7625. Western blot analysis of RANK expression in non-transfected: sc-117752 (A) and mouse RANK transfected: sc-122962 (B) 293T whole cell lysates.

RANK (T-19) - sc-34248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RANK (T-19): sc-34248. Western blot analysis of RANK expression in SJRH30 whole cell lysate.

RANK (64C1385.1) - sc-59981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RANK (64C1385.1): sc-59981. Western blot analysis of RANK expression in non-transfected: sc-117752 (A) and mouse RANK transfected: sc-122962 (B) 293T whole cell lysates.

RANK (9A725) - sc-52951 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-RANK antibody - ab200369 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RANK antibody (ab200369) at 1/200 dilutionLane 1 : Human liver tissue lysateLane 2 : Mouse kidney tissue lysateLysates/proteins at 40 µg per lane.

Anti-RANK antibody - ab10497 from Abcam

Prices $370.00
Sizes 25 µg
Host Goat
Clonality Polyclonal

Anti-RANK antibody - ab140459 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RANK antibody (ab140459) at 0.4 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-RANK antibody - ab22106 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RANK antibody (ab22106) + RAW cell lysate

Anti-RANK antibody [64C1385] - ab13918 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 64C1385
Detection of RANK in RAW cells. Lane 1: mouse cell line. Lane 2 & 3: IP/Western blot analysis of RANK. RANK protein from RAW cell lysate was immunoprecipitated either with control antibody (lane 2) or ab13918 (lane 3), and detected with ab13918.

Anti-RANK antibody [9A725] - ab12008 from Abcam

Prices $390.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 9A725
RANK detection by Western blot. The analysis of RANK in 293 cells transfected with RANK cDNA. A single protein band of approximate mol. wt. of 97 kDa was detected by using anti-RANK at 2 ug/ml.

Anti-RANK antibody [9A725] (Phycoerythrin) - ab45092 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9A725
Intracellular flow analysis of RANK in RAW cells using 0.5 µg of ab45092. Green histogram represents isotype control; red represents ab45092.

Anti-RANK antibody (Biotin) - ab17480 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-RANK antibody [EPR4740(N)] - ab182158 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4740(N)
All lanes : Anti-RANK antibody [EPR4740(N)] (ab182158) at 1/10000 dilutionLane 1 : Human adrenal gland tissue lysateLane 2 : Human fetal liver tissue lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution

Anti-RANK antibody [MM0521-7G22] - ab89912 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0521-7G22
Overlay histogram showing HepG2 cells stained with ab89912 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab88912, 0.5µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG2 (1µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HepG2 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-sRANKR antibody - ab83409 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-sRANKR antibody (Biotin) - ab83153 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF11A / RANK Antibody - LS-C17584 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF11A / RANK Antibody (aa326-616, PE) - LS-C17583 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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