| Gene Symbol |
TLK2
|
| Entrez Gene |
11011
|
| Alt Symbol |
HsHPK, PKU-ALPHA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tousled-like kinase 2
|
| Other Description |
serine/threonine-protein kinase tousled-like 2
|
| Swissprots |
Q9Y4F7 Q86UE8 Q9UKI7 D3DU07
|
| Accessions |
EAW94343 EAW94344 EAW94345 EAW94346 EAW94347 EAW94348 EAW94349 Q86UE8 AA430024 AB004884 BAA20561 AF162667 AAF03095 AI381985 AI621235 AK300586 BAG62284 AX775745 CAE11572 BC013736 BC044925 AAH44925 BC060511 BM668399 BX647225 XM_011524215 XP_011522517 XM_011524216 XP_011522518 XM_011524217 XP_011522519 XM_011524218 XP_011522520 XM_011524219 XP_011522521 XM_011524220 XP_011522522 XM_011524221 XP_011522523 XM_011524222 XP_011522524 XM_011524223 XP_011522525 XM_011524224 XP_011522526 XM_011524225 XP_011522527 XM_011524226 XP_011522528 XM_011524227 XP_011522529 XM_011524228 XP_011522530 XM_011524229 XP_011522531 XM_011524230 XP_011522532 XM_011524231 XP_011522533 NM_001284333 NP_001271262 NM_001284363 NP_001271292 NM_006852 NP_006843 NM_001112707
|
| Function |
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.
|
| Subcellular Location |
Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
|
| Tissue Specificity |
Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. {ECO:0000269|PubMed:9427565, ECO:0000269|PubMed:9662073}.
|
