TLK2

Gene Symbol	TLK2
Entrez Gene	11011
Alt Symbol	HsHPK, PKU-ALPHA
Species	Human
Gene Type	protein-coding
Description	tousled-like kinase 2
Other Description	serine/threonine-protein kinase tousled-like 2
Swissprots	Q9Y4F7 Q86UE8 Q9UKI7 D3DU07
Accessions	EAW94343 EAW94344 EAW94345 EAW94346 EAW94347 EAW94348 EAW94349 Q86UE8 AA430024 AB004884 BAA20561 AF162667 AAF03095 AI381985 AI621235 AK300586 BAG62284 AX775745 CAE11572 BC013736 BC044925 AAH44925 BC060511 BM668399 BX647225 XM_011524215 XP_011522517 XM_011524216 XP_011522518 XM_011524217 XP_011522519 XM_011524218 XP_011522520 XM_011524219 XP_011522521 XM_011524220 XP_011522522 XM_011524221 XP_011522523 XM_011524222 XP_011522524 XM_011524223 XP_011522525 XM_011524224 XP_011522526 XM_011524225 XP_011522527 XM_011524226 XP_011522528 XM_011524227 XP_011522529 XM_011524228 XP_011522530 XM_011524229 XP_011522531 XM_011524230 XP_011522532 XM_011524231 XP_011522533 NM_001284333 NP_001271262 NM_001284363 NP_001271292 NM_006852 NP_006843 NM_001112707
Function	Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.
Subcellular Location	Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Tissue Specificity	Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. {ECO:0000269|PubMed:9427565, ECO:0000269|PubMed:9662073}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TLK2 protein fragment - ab89855 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human TLK2 protein fragment - ab153152 from Abcam Category Protein Source Wheat germ Species Human

TLK2 Antibody Blocking Peptide - LS-E21338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TLK2 Antibody Blocking Peptide - LS-E21337 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TLK2 Antibody Blocking Peptide - LS-E9496 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TLK2 Protein - H00011011-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TLK2 Peptide - P3107 from Novus Biologicals Category Peptide Species Human

TLK2-Antibody-Center-Blocking-Peptide - BP8102c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLK2 Blocking Peptide - 33R-9798 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TLK2 Blocking Peptide - 33R-8656 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TLK2 - H00011011-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TLK2 - H00011011-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TLK2 - P5652 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

TLK2 fusion protein - Ag5022 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Tousled-like Kinase 2, GST-tagged, Active - TLK2-446H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human TLK2 - TLK2-30422TH from Creative Biomart Category Protein

Recombinant Human TLK2, His & GST tagged - TLK2-1362H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human TLK2, Gly & Pro tagged - TLK2-270H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human TLK2, GST-tagged - TLK2-3253H from Creative Biomart Category Protein Source E.coli Species Human

Human TLK2 / PKU-ALPHA Protein (aa 397-772) - 11551-HNCB-100 from Sino Biological Category Protein Prices $258.00, $258.00, $258.00 Sizes 20 µg, 50 µg, 100 µg Source Baculovirus-Insect Cells Species Human

Human TLK2 / PKU-ALPHA Protein (aa 397-772, His & GST Tag) - 11551-H20B-100 from Sino Biological Category Protein Prices $348.00, $348.00, $348.00 Sizes 20 µg, 50 µg, 100 µg Source Baculovirus-Insect Cells Species Human

TLK2 Protein, active, 250 µg - 14-739M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-739) and in bulk (cat# 14-739-K) Source Expressed by baculovirus in Sf21 cells.

TLK2 Protein, active, 10 µg - 14-739 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg also available in 250μg size as catalog # 14-739m - call for pricing and availability. Source Expressed by baculovirus in Sf21 cells.

Recombinant Human Serine/threonine-protein kinase tousled-like 2(TLK2) - CSB-YP801231HU CSB-EP801231HU CSB-BP801231HU CSB-MP801231HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TLK2 (transcript variant A) - TP318935 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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