TLK2

Gene Symbol TLK2
Entrez Gene 11011
Alt Symbol HsHPK, PKU-ALPHA
Species Human
Gene Type protein-coding
Description tousled-like kinase 2
Other Description serine/threonine-protein kinase tousled-like 2
Swissprots Q9Y4F7 Q86UE8 Q9UKI7 D3DU07
Accessions EAW94343 EAW94344 EAW94345 EAW94346 EAW94347 EAW94348 EAW94349 Q86UE8 AA430024 AB004884 BAA20561 AF162667 AAF03095 AI381985 AI621235 AK300586 BAG62284 AX775745 CAE11572 BC013736 BC044925 AAH44925 BC060511 BM668399 BX647225 XM_011524215 XP_011522517 XM_011524216 XP_011522518 XM_011524217 XP_011522519 XM_011524218 XP_011522520 XM_011524219 XP_011522521 XM_011524220 XP_011522522 XM_011524221 XP_011522523 XM_011524222 XP_011522524 XM_011524223 XP_011522525 XM_011524224 XP_011522526 XM_011524225 XP_011522527 XM_011524226 XP_011522528 XM_011524227 XP_011522529 XM_011524228 XP_011522530 XM_011524229 XP_011522531 XM_011524230 XP_011522532 XM_011524231 XP_011522533 NM_001284333 NP_001271262 NM_001284363 NP_001271292 NM_006852 NP_006843 NM_001112707
Function Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.
Subcellular Location Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Tissue Specificity Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. {ECO:0000269|PubMed:9427565, ECO:0000269|PubMed:9662073}.

TLK2 (E-12) - sc-393506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLK2 (E-12): sc-393506. Western blot analysis of TLK2 expression in HeLa nuclear extract (A), NTERA-2 cl.D1 (B) and Y79 (C) whole cell lysates and rat testis (D) and human testis (E) tissue extracts.

TLK2 (C-15) - sc-11600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK2 (C-15): sc-11600. Western blot analysis of TLK2 expression in Sol8 whole cell lysate.

TLK2 (H-141) - sc-367961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TLK2 (L-15) - sc-11599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLK2 (L-15): sc-11599. Western blot analysis of TLK2 expression in Y79 whole cell lysate.

TLK2 (Y-17) - sc-100346 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TLK2 (Y-17): sc-100346. Western blot analysis of TLK2 expression in HeLa nuclear extract.

Anti-TLK2 antibody - ab56816 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TLK2 antibody (ab56816) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human colon tissue.

Anti-TLK2 antibody - ab135818 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TLK2 antibody (ab135818) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

Anti-TLK2 antibody - ab74335 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLK2 antibody (ab74335) at 0.4 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 5 µgLane 4 : HeLa whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-TLK2 antibody - ab87086 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TLK2 antibody (ab87086) at 1 µg/ml (5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TLK2 Antibody (Internal, AP) - LS-C283635 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (Internal, APC) - LS-C283637 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (Internal, Biotin) - LS-C283638 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (Internal, FITC) - LS-C283639 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (Internal, Azide-free, HRP) - LS-C283641 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (Internal, PE) - LS-C283640 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (aa181-230) - LS-C200789 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using TLK2 antibody.

Anti-TLK2 Antibody (aa722-772) - LS-C288068 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (aa1-126, Azide-free) - LS-C328899 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TLK2 Antibody (Internal) - LS-C328900 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLK2 Antibody (aa191-240) - LS-C120374 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO cells, using TLK2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-TLK2 Antibody (aa35-84) - LS-C117214 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TLK2 antibody LS-C117214 Western blot of Jurkat lysate.

Anti-TLK2 Antibody (aa176-225) - LS-C112180 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TLK2 antibody LS-C112180 Western blot of 721_B cell lysate.

Anti-TLK2 Antibody - LS-C334934 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U2OS cell using TLK2 antibody. Blue: DAPI for nuclear staining.

Anti-TLK2 Antibody (aa1-296, clone 3F2) - LS-C339603 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F2
IHC of paraffin-embedded Human tonsil using anti-TLK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-TLK2 Antibody (aa1-296, clone 2F9) - LS-C339602 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F9
IHC of paraffin-embedded Human tonsil using anti-TLK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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