TLK2

Gene Symbol TLK2
Entrez Gene 11011
Alt Symbol HsHPK, PKU-ALPHA
Species Human
Gene Type protein-coding
Description tousled-like kinase 2
Other Description serine/threonine-protein kinase tousled-like 2
Swissprots Q9Y4F7 Q86UE8 Q9UKI7 D3DU07
Accessions EAW94343 EAW94344 EAW94345 EAW94346 EAW94347 EAW94348 EAW94349 Q86UE8 AA430024 AB004884 BAA20561 AF162667 AAF03095 AI381985 AI621235 AK300586 BAG62284 AX775745 CAE11572 BC013736 BC044925 AAH44925 BC060511 BM668399 BX647225 XM_011524215 XP_011522517 XM_011524216 XP_011522518 XM_011524217 XP_011522519 XM_011524218 XP_011522520 XM_011524219 XP_011522521 XM_011524220 XP_011522522 XM_011524221 XP_011522523 XM_011524222 XP_011522524 XM_011524223 XP_011522525 XM_011524224 XP_011522526 XM_011524225 XP_011522527 XM_011524226 XP_011522528 XM_011524227 XP_011522529 XM_011524228 XP_011522530 XM_011524229 XP_011522531 XM_011524230 XP_011522532 XM_011524231 XP_011522533 NM_001284333 NP_001271262 NM_001284363 NP_001271292 NM_006852 NP_006843 NM_001112707
Function Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.
Subcellular Location Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Tissue Specificity Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. {ECO:0000269|PubMed:9427565, ECO:0000269|PubMed:9662073}.

TLK2 CRISPR/Cas9 KO Plasmid (h) - sc-405426 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 HDR Plasmid (h) - sc-405426-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 Double Nickase Plasmid (h) - sc-405426-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 Double Nickase Plasmid (h2) - sc-405426-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 CRISPR Activation Plasmid (h) - sc-405426-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 CRISPR Activation Plasmid (h2) - sc-405426-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 Lentiviral Activation Particles (h) - sc-405426-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 Lentiviral Activation Particles (h2) - sc-405426-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLK2 siRNA (h) - sc-106801 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLK2 shRNA Plasmid (h) - sc-106801-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLK2 shRNA (h) Lentiviral Particles - sc-106801-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLK2 RNAi - H00011011-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113941 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK2298 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2296 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2299 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2294 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2297 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2295 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21395 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21395 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08017 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08017

TLK2 siRNA (Human) - CRH7520 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLK2 - MBS8217146 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TLK2(NM_006852.3) - SHL072678 from Creative biogene

Category siRNA
Species Reactivities Human
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