FAP

Gene Symbol	FAP
Entrez Gene	2191
Alt Symbol	DPPIV, FAPA, SIMP
Species	Human
Gene Type	protein-coding
Description	fibroblast activation protein, alpha
Other Description	170 kDa melanoma membrane-bound gelatinase|FAPalpha|dipeptidyl peptidase FAP|gelatine degradation protease FAP|integral membrane serine protease|post-proline cleaving enzyme|prolyl endopeptidase FAP|seprase|serine integral membrane protease|surface-expressed protease
Swissprots	Q86Z29 Q12884 Q9UID4 Q99998 Q53TP5 O00199
Accessions	AAY24205 EAX11353 EAX11354 Q12884 AK055327 AK297118 BAG59624 AK309260 AK310293 AK315448 BAG37836 AL832166 BC026250 AAH26250 DQ891423 ABM82349 DQ894597 ABM85523 U09278 AAB49652 U76833 AAC51668 XM_011510796 XP_011509098 XM_011510797 XP_011509099 XR_922890 XR_922891 NM_001291807 NP_001278736 NM_004460 NP_004451
Function	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000303|PubMed:10644713}.
Tissue Specificity	Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines. {ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10644713, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:7911242}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FAP Human ELISA Kit - ab193701 from Abcam Category ELISA Kit Prices $475.00 Sizes 1 x 96 tests Sensitivity 12 pg/ml Range 12 pg/ml - 4000 pg/ml

Human FAP Alpha ELISA Kit (Sandwich ELISA) - LS-F2824 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 16.38-1600 pg/ml

Mouse/Human/Rat FAP Alpha ELISA Kit (Cell-Based ELISA) - LS-F1983 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 16.38-1600 pg/ml

Human FAP Alpha ELISA Kit (Sandwich ELISA) - LS-F80 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 16.38 pg/ml Range 16.38-1600 pg/ml

Mouse FAP Alpha ELISA Kit (Sandwich ELISA) - LS-F7697 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 16.38-1600 pg/ml

Human FAP Alpha ELISA Kit (Sandwich ELISA) - LS-F8125 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 16.38-1600 pg/ml

Rat FAP Alpha ELISA Kit (Sandwich ELISA) - LS-F8638 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 16.38-1600 pg/ml

Human FAP / Seprase ELISA Kit - RAB0538 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt Sensitivity 12 pg/ml

Seprase/FAP BioAssay™ ELISA Kit, Human - 144037 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 62.5pg/ml-4000pg/ml

Human FAP DuoSet ELISA - DY3715 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human FAPa ELISA Kit - abx151488 from Abbexa Category ELISA Kit Sensitivity 0.28 ng/ml Range 0.781 ng/ml - 50 ng/ml

Fibroblast Activation Protein Alpha (FAPa), Human, ELISA Kit - SEC469Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.28ng/mL Range 0.78 -50ng/mL

Seprase (FAP), Human, ELISA Kit - CSB-EL008424HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.195 ng/ml Range 0.78 ng/ml-50 ng/ml

dipeptidyl peptldase IV, DPPIV, Mouse, ELISA Kit - E-EL-M0418 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

FAP (Human) IP-WB Antibody Pair - H00002191-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FAP (Human) Matched Antibody Pair - H00002191-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human FAP ELISA - ELH-FAP from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 12 pg/ml Range 12 pg/ml - 4000 pg/ml

FAP-1 Colorimetric Cell-Based ELISA Kit - CB5257 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human DPPIV/CD26 ELISA Kit - DEIA2831 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of CD26 is typically less than 25 pg/ml. Range 25 pg/ml - 8000 pg/ml

Human DPPIV ELISA Kit - DEIA7878 from Creative Diagnostics Category ELISA Kit

FAP alpha, ELISA Kit - MBS824973 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 62.5 pg/ml - 4000 pg/ml

FAPalpha, ELISA Kit - MBS2515951 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

Fibroblast Activation Protein Alpha (FAPa), ELISA Kit - MBS2024462 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.31ng/mL. Range 0.781-50ng/mL

Fibroblast Activation Protein Alpha (FAPa), ELISA Kit - MBS2021908 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.117ng/mL. Range 0.313-20ng/mL

Fibroblast Activation Protein Alpha (FAPa), ELISA Kit - MBS9307927 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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