FAP

Gene Symbol	FAP
Entrez Gene	2191
Alt Symbol	DPPIV, FAPA, SIMP
Species	Human
Gene Type	protein-coding
Description	fibroblast activation protein, alpha
Other Description	170 kDa melanoma membrane-bound gelatinase|FAPalpha|dipeptidyl peptidase FAP|gelatine degradation protease FAP|integral membrane serine protease|post-proline cleaving enzyme|prolyl endopeptidase FAP|seprase|serine integral membrane protease|surface-expressed protease
Swissprots	Q86Z29 Q12884 Q9UID4 Q99998 Q53TP5 O00199
Accessions	AAY24205 EAX11353 EAX11354 Q12884 AK055327 AK297118 BAG59624 AK309260 AK310293 AK315448 BAG37836 AL832166 BC026250 AAH26250 DQ891423 ABM82349 DQ894597 ABM85523 U09278 AAB49652 U76833 AAC51668 XM_011510796 XP_011509098 XM_011510797 XP_011509099 XR_922890 XR_922891 NM_001291807 NP_001278736 NM_004460 NP_004451
Function	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000303|PubMed:10644713}.
Tissue Specificity	Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines. {ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10644713, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:7911242}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Fibroblast activation protein, alpha protein fragment - ab79623 from Abcam Category Protein Prices $447.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Fibroblast activation protein, alpha peptide - ab41274 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Fibroblast activation protein, alpha peptide - ab41275 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Fibroblast activation protein, alpha peptide - ab41276 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Fibroblast activation protein, alpha peptide - ab41277 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Fibroblast activation protein, alpha peptide - ab150744 from Abcam Category Peptide Prices $176.00 Sizes 200 µg

Human Fibroblast activation protein, alpha full length protein - ab132355 from Abcam Category Protein Source Wheat germ Species Human

Human Fibroblast activation protein, alpha protein fragment - ab117468 from Abcam Category Protein Source E. coli Species Human

FAP-Antibody-Center-Blocking-peptide - BP13766c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FAP, CF - 3715-SE-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu26-Asp760, with an N-terminal 6-His tag

Recombinant human Seprase (OPCA00084) - OPCA00084 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Seprase Protein (OPPA01872) - OPPA01872 from Aviva Systems Biology Category Protein Prices $280.00 Sizes 2 µg Source E. Coli

Human FAP protein - orb244197 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Fibroblast Activation Protein Alpha protein - orb90263 from Biorbyt Category Protein Prices $408.00, $595.00, $935.00 Sizes 2 μg, 5 μg, 10 μg Source E.coli Species Human

DPP4 protein - 30R-1195 from Fitzgerald Category Protein Prices $395.00 Sizes 100 µg Source Hi-5 cells

Seprase / FAP - H00002191-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Seprase / FAP - H00002191-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Seprase / FAP - H00002191-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FAPA fusion protein - ag2439 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DPP4 Human - ENPS-389 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 ng, 10 ng, 700 ng Source Human Placenta. Species Human

Seprase Human - ENPS-472 from NeoScientific Category Protein Prices $351.00, $637.00 Sizes 5 µg, 10 µg Source Escherichia Coli. Species Human

Human Dipeptidyl Peptidase 4 - BP000755-ENZ-375 from Syd Labs Category Protein Prices $160.00, $4,000.00 Sizes 10 µg, 1 mg Source High-5 cells-derived. Species Human

Recombinant Human Dipeptidyl-Peptidase 4 - BP000755-ENZ-382 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source Human Placenta-derived. Species Human

Recombinant Human Fibroblast Activation Protein Alpha - BP000726-ENZ-465 from Syd Labs Category Protein Prices $175.00, $270.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source E. coli-derived. Species Human

Recombinant Human Fibroblast Activation Protein Alpha - GWB-5DE407 from Genway Biotech Category Protein Prices $245.00, $375.00, $665.00 Sizes 2 μg, 5 μg, 10 μg Species Human

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