FAP

Gene Symbol	FAP
Entrez Gene	2191
Alt Symbol	DPPIV, FAPA, SIMP
Species	Human
Gene Type	protein-coding
Description	fibroblast activation protein, alpha
Other Description	170 kDa melanoma membrane-bound gelatinase|FAPalpha|dipeptidyl peptidase FAP|gelatine degradation protease FAP|integral membrane serine protease|post-proline cleaving enzyme|prolyl endopeptidase FAP|seprase|serine integral membrane protease|surface-expressed protease
Swissprots	Q86Z29 Q12884 Q9UID4 Q99998 Q53TP5 O00199
Accessions	AAY24205 EAX11353 EAX11354 Q12884 AK055327 AK297118 BAG59624 AK309260 AK310293 AK315448 BAG37836 AL832166 BC026250 AAH26250 DQ891423 ABM82349 DQ894597 ABM85523 U09278 AAB49652 U76833 AAC51668 XM_011510796 XP_011509098 XM_011510797 XP_011509099 XR_922890 XR_922891 NM_001291807 NP_001278736 NM_004460 NP_004451
Function	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000303|PubMed:10644713}.
Tissue Specificity	Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines. {ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10644713, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:7911242}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FAP 293T Cell Transient Overexpression Lysate(Denatured) - H00002191-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

FAP overexpression lysate - LY401418 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FAP 293 Cell Lysate - 401291 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Fibroblast Activation Protein alpha/FAP Overexpression Lysate (Denatured) - H00002191-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Fibroblast Activation Protein alpha/FAP Overexpression Lysate (Native) - NBL1-10592 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FAP Over-expression Lysate Product - GWB-6C1B88 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Cynomolgus DPP4 / DPPIV / CD26 HEK293 Cell Lysate (WB positive control) - 90180-C01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human DPP4 / DPPIV / CD26 HEK293 Cell Lysate (WB positive control) - 10688-HNCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human DPP4 / DPPIV / CD26 HEK293 Cell Lysate (WB positive control) - 10688-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human DPPIV Human Cells Transfected Lysate (positive control) (denatured) - orb172878 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human DPPIV Human Cells Transfected Lysate (positive control) (denatured) - orb172877 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

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