FAP

Gene Symbol FAP
Entrez Gene 2191
Alt Symbol DPPIV, FAPA, SIMP
Species Human
Gene Type protein-coding
Description fibroblast activation protein, alpha
Other Description 170 kDa melanoma membrane-bound gelatinase|FAPalpha|dipeptidyl peptidase FAP|gelatine degradation protease FAP|integral membrane serine protease|post-proline cleaving enzyme|prolyl endopeptidase FAP|seprase|serine integral membrane protease|surface-expressed protease
Swissprots Q86Z29 Q12884 Q9UID4 Q99998 Q53TP5 O00199
Accessions AAY24205 EAX11353 EAX11354 Q12884 AK055327 AK297118 BAG59624 AK309260 AK310293 AK315448 BAG37836 AL832166 BC026250 AAH26250 DQ891423 ABM82349 DQ894597 ABM85523 U09278 AAB49652 U76833 AAC51668 XM_011510796 XP_011509098 XM_011510797 XP_011509099 XR_922890 XR_922891 NM_001291807 NP_001278736 NM_004460 NP_004451
Function Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residu
Subcellular Location Isoform 2: Cytoplasm {ECO:0000303|PubMed:10644713}.
Tissue Specificity Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines. {ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10644713, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:7911242}.

FAP (6D394) - sc-71094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

FAP (F11-24) - sc-65398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

FAPα (H-56) - sc-135069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAPα (H-56): sc-135069. Western blot analysis of FAPα expression in mouse skin tissue extract.

FAPα (C-19) - sc-54539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FAPα (Y-16) - sc-54538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FAPα (SS-13) - sc-100528 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
FAPα (SS-13): sc-100528. Western blot analysis of FAPα expression in Hep G2 whole cell lysate.

Anti-Fibroblast activation protein, alpha antibody - ab53066 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fibroblast activation protein, alpha antibody (ab53066) at 1/500 dilutionLane 1 : LOVO cell extractLane 2 : LOVO cell extract with immunising peptideObserved band size : 90 kDa (why is the actual band size different from the predicted?)

Anti-Fibroblast activation protein, alpha antibody - ab28244 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fibroblast activation protein, alpha antibody (ab28244) at 1/1000 dilutionLane 1 : Recombinant Human FAPalpha at 0.08 µgLane 2 : Recombinant Human FAPalpha at 0.04 µgLane 3 : Recombinant Human FAPalpha at 0.02 µgLane 4 : Recombinant Human FAPalpha at 0.01 µgLane 5 : Recombinant Human FAPalpha at 0.005 µg

Anti-Fibroblast activation protein, alpha antibody - ab28245 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fibroblast activation protein, alpha antibody (ab28245) at 1/1000 dilutionLane 1 : r-Human FAPalpha at 0.08 µgLane 2 : r-Human FAPalpha at 0.04 µgLane 3 : r-Human FAPalpha at 0.02 µgLane 4 : r-Human FAPalpha at 0.01 µgLane 5 : r-Human FAPalpha at 0.005 µg

Anti-Fibroblast activation protein, alpha antibody - ab54651 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Fibroblast activation protein, alpha antibody [MM0617-16F50] - ab135176 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0617-16F50

Anti-Fibroblast activation protein, alpha antibody - Catalytic domain - ab28243 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fibroblast activation protein, alpha antibody - Catalytic domain (ab28243) at 1/1000 dilutionLane 1 : r-Human FAPalpha at 0.08 µgLane 2 : r-Human FAPalpha at 0.04 µgLane 3 : r-Human FAPalpha at 0.02 µgLane 4 : r-Human FAPalpha at 0.01 µgLane 5 : r-Human FAPalpha at 0.005 µg

Anti-FAP Alpha Antibody (aa57-73) - LS-C313051 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
FAP Alpha antibody. IHC(P): Rat Spleen Tissue.

Anti-FAP Alpha Antibody (clone F11-24) - LS-C6818 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone F11-24

Anti-FAP Alpha Antibody (aa26-760, clone 9H122) - LS-C125605 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9H122

Anti-FAP Alpha Antibody (clone 2F2) - LS-C139462 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F2

Anti-FAP Alpha Antibody (aa525-625, Azide-free) - LS-C183626 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FAP Alpha Antibody (clone F11-24) - LS-C194748 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone F11-24

Anti-FAP Alpha Antibody (AP) - LS-C222497 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (Biotin) - LS-C222499 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (APC) - LS-C222498 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (Azide-free, HRP) - LS-C222500 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (FITC) - LS-C222501 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (PE) - LS-C222502 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP Alpha Antibody (aa396-426, Biotin) - LS-C222505 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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