TLE2

Gene Symbol TLE2
Entrez Gene 7089
Alt Symbol ESG, ESG2, GRG2
Species Human
Gene Type protein-coding
Description transducin-like enhancer of split 2
Other Description enhancer of split groucho-like protein 2|transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)|transducin-like enhancer of split 2, homolog of Drosophila E(sp1)|transducin-like enhancer protein 2
Swissprots E9PEV7 F8WCH2 Q04725 Q8WVY0 Q9Y6S0 B4DE03
Accessions AAD38075 EAW69348 EAW69349 Q04725 AK123183 AK293407 BAG56914 AK293482 BAG56973 AK303102 BAG64211 AK308137 AK308608 AK312285 AW262763 BC017364 AAH17364 HY046309 HY140405 JF432328 ADZ15545 M99436 AAA61193 XM_005259637 XP_005259694 XM_006722864 XP_006722927 XM_011528230 XP_011526532 NM_001144761 NP_001138233 NM_001144762 NP_001138234 NM_001300846 NP_001287775 NM_003260 NP_003251
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity In all tissues examined, mostly in heart, brain, and muscle.

TLE2 (D-10) - sc-374226 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLE2 (D-10): sc-374226. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.

TLE2 (H-191) - sc-9122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLE2 (H-191): sc-9122. Western blot analysis of polyhistidine-tagged human recombinant TLE2.

TLE2 (H-321) - sc-9123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLE2 (H-321): sc-9123. Western blot analysis of His-tagged human recombinant TLE2.

TLE2 (N-20) - sc-13370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TLE2 antibody - ab128182 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLE2 antibody (ab128182) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-TLE2 antibody - ab80557 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TLE2 antibody (ab80557) at 1 µg/ml + Transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TLE2 antibody - ab136961 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TLE2 antibody (ab136961) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-TLE2 antibody - ab72634 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-TLE2 antibody (ab72634) at 1/500 dilutionLane 1 : TLE2-transfected 293T cell line lysateLane 2 : Non-transfected lysateLysates/proteins at 25 µg per lane.SecondaryHRP-conjugated goat anti-mouse IgG at 1/2500 dilution

Anti-TLE2 antibody - C-terminal - ab170608 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TLE2 antibody - C-terminal (ab170608) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

Anti-TLE2 Antibody (aa220-235) - LS-C7309 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa201-250) - LS-C80001 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TLE2 Antibody (aa204-234) - LS-C161910 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TLE2 Antibody (Center) in 293, K562 cell line lysates (35 ug/lane). TLE2 (arrow) was detected using the purified Pab.

Anti-TLE2 Antibody (aa165-214) - LS-C200788 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HT-29 cells using TLE2 antibody.

Anti-TLE2 Antibody (aa637-665, AP) - LS-C217940 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa637-665) - LS-C161909 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TLE2 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The TLE2 antibody detected the TLE2 protein (arrow).

Anti-TLE2 Antibody (aa637-665, APC) - LS-C217941 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa637-665, Biotin) - LS-C217942 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (Lys214) - LS-C176795 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TLE2 (K214) pAb in extracts from HeLa cells.

Anti-TLE2 Antibody (aa637-665, FITC) - LS-C217943 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa211-260) - LS-C118987 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from LOVO cells, using TLE2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-TLE2 Antibody (aa637-665, Azide-free, HRP) - LS-C217944 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa637-665, PE) - LS-C217945 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa636-665) - LS-C325745 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLE2 Antibody (aa200-250) - LS-C290263 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TLE2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-TLE2 antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. TLE2 was also immunoprecipitated by rabbit anti-TLE2 antibody BL12876, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A and B).

Anti-TLE2 Antibody (clone 5A6) - LS-C173715 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TLE2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TLE2.
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