Gene Symbol | TLE2 |
---|---|
Entrez Gene | 7089 |
Alt Symbol | ESG, ESG2, GRG2 |
Species | Human |
Gene Type | protein-coding |
Description | transducin-like enhancer of split 2 |
Other Description | enhancer of split groucho-like protein 2|transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)|transducin-like enhancer of split 2, homolog of Drosophila E(sp1)|transducin-like enhancer protein 2 |
Swissprots | E9PEV7 F8WCH2 Q04725 Q8WVY0 Q9Y6S0 B4DE03 |
Accessions | AAD38075 EAW69348 EAW69349 Q04725 AK123183 AK293407 BAG56914 AK293482 BAG56973 AK303102 BAG64211 AK308137 AK308608 AK312285 AW262763 BC017364 AAH17364 HY046309 HY140405 JF432328 ADZ15545 M99436 AAA61193 XM_005259637 XP_005259694 XM_006722864 XP_006722927 XM_011528230 XP_011526532 NM_001144761 NP_001138233 NM_001144762 NP_001138234 NM_001300846 NP_001287775 NM_003260 NP_003251 |
Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | In all tissues examined, mostly in heart, brain, and muscle. |
TLE2 CRISPR/Cas9 KO Plasmid (h) - sc-402718 from Santa Cruz Biotechnology
|
||||||||
TLE2 HDR Plasmid (h) - sc-402718-HDR from Santa Cruz Biotechnology
|
||||||||
TLE2 Double Nickase Plasmid (h) - sc-402718-NIC from Santa Cruz Biotechnology
|
||||||||
TLE2 Double Nickase Plasmid (h2) - sc-402718-NIC-2 from Santa Cruz Biotechnology
|
||||||||
TLE2 CRISPR Activation Plasmid (h) - sc-402718-ACT from Santa Cruz Biotechnology
|
||||||||
TLE2 CRISPR Activation Plasmid (h2) - sc-402718-ACT-2 from Santa Cruz Biotechnology
|
||||||||
TLE2 Lentiviral Activation Particles (h) - sc-402718-LAC from Santa Cruz Biotechnology
|
||||||||
TLE2 Lentiviral Activation Particles (h2) - sc-402718-LAC-2 from Santa Cruz Biotechnology
|
||||||||
TLE2 siRNA (h) - sc-38560 from Santa Cruz Biotechnology
|
||||||||
TLE2 shRNA Plasmid (h) - sc-38560-SH from Santa Cruz Biotechnology
|
||||||||
TLE2 shRNA (h) Lentiviral Particles - sc-38560-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU076091 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN21390 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21390 from Sigma-Aldrich
|
||||||||
TLE2 siRNA (Human) - CRH4856 from Cohesion Biosciences
|
||||||||
TLE2 - MBS8228852 from MyBioSource
|
||||||||
shRNA set against Human TLE2 (NM_003260.4) - SHH427804 from Creative biogene
|
||||||||
Human TLE2 siRNA - orb265358 from Biorbyt
|
||||||||
TLE2 shRNA Plasmid (Human) - CHH4856 from Cohesion Biosciences
|
||||||||
TLE2 miRNA 3'UTR clone - MiUTR3H-03835 from Creative biogene
|
||||||||
TLE2 miRNA 3'UTR clone - MiUTR3H-03836 from Creative biogene
|
||||||||
TLE2 miRNA 3'UTR clone - MiUTR3H-03837 from Creative biogene
|