| Gene Symbol |
TLE2
|
| Entrez Gene |
7089
|
| Alt Symbol |
ESG, ESG2, GRG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transducin-like enhancer of split 2
|
| Other Description |
enhancer of split groucho-like protein 2|transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)|transducin-like enhancer of split 2, homolog of Drosophila E(sp1)|transducin-like enhancer protein 2
|
| Swissprots |
E9PEV7 F8WCH2 Q04725 Q8WVY0 Q9Y6S0 B4DE03
|
| Accessions |
AAD38075 EAW69348 EAW69349 Q04725 AK123183 AK293407 BAG56914 AK293482 BAG56973 AK303102 BAG64211 AK308137 AK308608 AK312285 AW262763 BC017364 AAH17364 HY046309 HY140405 JF432328 ADZ15545 M99436 AAA61193 XM_005259637 XP_005259694 XM_006722864 XP_006722927 XM_011528230 XP_011526532 NM_001144761 NP_001138233 NM_001144762 NP_001138234 NM_001300846 NP_001287775 NM_003260 NP_003251
|
| Function |
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
In all tissues examined, mostly in heart, brain, and muscle.
|
![Western Blot: TLE2 Overexpression Lysate (Adult Normal) [NBL1-16945] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TLE2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12227_TLE2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-16945-img0002.jpg)