| Gene Symbol |
TGS1
|
| Entrez Gene |
96764
|
| Alt Symbol |
NCOA6IP, PIMT, PIPMT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trimethylguanosine synthase 1
|
| Other Description |
CLL-associated antigen KW-2|PRIP-interacting protein PIPMT|PRIP-interacting protein with methyltransferase domain|PRIP-interacting protein with methyltransferase motif|SEREX-defined|cap-specific guanine-N2 methyltransferase|hepatocellular carcinoma-associated antigen 137|nuclear receptor coactivator 6 interacting protein|nuclear receptor coactivator 6-interacting protein|trimethylguanosine synthase|trimethylguanosine synthase homolog
|
| Swissprots |
Q8TDG9 A6NJQ5 Q96QU3 Q5GH23 Q96RS0 Q9H5V3
|
| Accessions |
EAW86761 EAW86762 EAW86763 Q96RS0 AF286340 AAK83025 AF432215 AAL99922 AK026648 BAB15516 AK055178 BAG51481 AK314693 BAG37244 AL832426 AY028423 AAK27730 AY534911 AAT02709 BC011999 AAH11999 BC160105 AAI60105 BM853546 BX648548 DB082992 XM_005251328 XP_005251385 XM_006716485 XP_006716548 XM_006716486 XP_006716549 NM_024831 NP_079107
|
| Function |
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
|
| Subcellular Location |
Cytoplasm. Nucleus, Cajal body. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
|
| Tissue Specificity |
Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:11517327}.
|
| Top Pathways |
RNA transport
|