TGS1

Gene Symbol	TGS1
Entrez Gene	96764
Alt Symbol	NCOA6IP, PIMT, PIPMT
Species	Human
Gene Type	protein-coding
Description	trimethylguanosine synthase 1
Other Description	CLL-associated antigen KW-2|PRIP-interacting protein PIPMT|PRIP-interacting protein with methyltransferase domain|PRIP-interacting protein with methyltransferase motif|SEREX-defined|cap-specific guanine-N2 methyltransferase|hepatocellular carcinoma-associated antigen 137|nuclear receptor coactivator 6 interacting protein|nuclear receptor coactivator 6-interacting protein|trimethylguanosine synthase|trimethylguanosine synthase homolog
Swissprots	Q8TDG9 A6NJQ5 Q96QU3 Q5GH23 Q96RS0 Q9H5V3
Accessions	EAW86761 EAW86762 EAW86763 Q96RS0 AF286340 AAK83025 AF432215 AAL99922 AK026648 BAB15516 AK055178 BAG51481 AK314693 BAG37244 AL832426 AY028423 AAK27730 AY534911 AAT02709 BC011999 AAH11999 BC160105 AAI60105 BM853546 BX648548 DB082992 XM_005251328 XP_005251385 XM_006716485 XP_006716548 XM_006716486 XP_006716549 NM_024831 NP_079107
Function	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Subcellular Location	Cytoplasm. Nucleus, Cajal body. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
Tissue Specificity	Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:11517327}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIMT full length protein - ab164972 from Abcam Category Protein Source Wheat germ Species Human

TGS1 / PIMT Antibody Blocking Peptide - LS-E17694 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIMT Protein - H00096764-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human TGS1 protein - orb246271 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

TGS1 Blocking Peptide - 33R-3910 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TGS1 - H00096764-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TGS1 - H00096764-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TGS1 fusion protein - ag3683 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Trimethylguanosine synthase(TGS1) ,partial - CSB-YP847219HU CSB-BP847219HU CSB-MP847219HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Trimethylguanosine synthase - CSB-EP847219HU from Cusabio Category Protein Source E.coli Species Human

TGS1 Protein - abx163954 from Abbexa Category Protein Species Human

PIMT Recombinant Protein Antigen - NBP1-92271PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PIMT-PIPMT-Antibody-Center-Blocking-peptide - BP1921b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIMT-PIPMT-Antibody-Center-G406-Blocking-peptide - BP1921a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIPMT-Antibody-N-term-Blocking-Peptide - BP1908a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TGS1 Peptide, Human - M34GP15883H from Creative Peptides Category Peptide Source Synthetic. Species Human

TGS1 Recombinant Protein (OPCA02418) - OPCA02418 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Trimethylguanosine synthase - AP71464 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

PIMT Recombinant Protein Antigen - NBP2-56790PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human TGS1 Protein (713-853 aa), His-SUMO-tagged - TGS1-1092H from Creative Biomart Category Protein Source E. coli Species Human

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