Gene Symbol | ADGRL1 |
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Entrez Gene | 22859 |
Alt Symbol | CIRL1, CL1, LEC2, LPHN1 |
Species | Human |
Gene Type | protein-coding |
Description | adhesion G protein-coupled receptor L1 |
Other Description | CIRL-1|calcium-independent alpha-latrotoxin receptor 1|latrophilin 1|latrophilin-1|lectomedin-2 |
Swissprots | Q9HAR3 Q9BU07 O94910 Q96IE7 |
Accessions | BAC06134 CAE90282 EAW84404 EAW84405 EAW84406 EAW84407 EAW84408 EAW84409 O94910 AB020628 BAA74844 AF307079 AAG27461 AK022001 BAB13950 BC002974 AAH02974 BC007587 AAH07587 BC013275 BC019928 BC028296 AAH28296 BC052627 BC072445 BC090949 BC168378 AAI68378 XM_005259818 XP_005259875 XM_005259819 XP_005259876 XM_011527796 XP_011526098 XM_011527797 XP_011526099 XM_011527798 XP_011526100 XM_011527799 XP_011526101 XM_011527800 XP_011526102 XM_011527801 XP_011526103 XM_011527802 XP_011526104 NM_001008701 NP_001008701 NM_014921 NP_055736 |
Function | Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250}. |
Human LPHN1 full length protein - ab161446 from Abcam
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Human LPHN1 protein fragment - ab161447 from Abcam
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ADGRL1 / LPHN1 Antibody Blocking Peptide - LS-E28145 from LifeSpan Bioscience
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ADGRL1 / LPHN1 Antibody Blocking Peptide - LS-E28146 from LifeSpan Bioscience
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ADGRL1 / LPHN1 Antibody Blocking Peptide - LS-E23947 from LifeSpan Bioscience
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Recombinant Human Latrophilin 1/LPHN1 Protein - H00022859-P01 from Novus Biologicals
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Recombinant Human Latrophilin 1/LPHN1 Protein - H00022859-Q01 from Novus Biologicals
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Recombinant Human Latrophilin 1/LPHN1 Protein - H00022859-G01 from Novus Biologicals
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LPHN1 Blocking Peptide - abx161148 from Abbexa
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Latrophilin-1 - H00022859-G01 from Acris Antibodies
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Latrophilin-1 - H00022859-P01-10 from Acris Antibodies
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Latrophilin-1 - H00022859-P01-25 from Acris Antibodies
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Latrophilin-1 - H00022859-Q01-10 from Acris Antibodies
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Latrophilin-1 - H00022859-Q01-25 from Acris Antibodies
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LPHN1 fusion protein - Ag3943 from Proteintech Group
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Recombinant Human LPHN1, GST-tagged - LPHN1-625H from Creative Biomart
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LPHN1 Blocking Peptide - CBP3647 from Cohesion Biosciences
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Latrophilin 1/LPHN1 Recombinant Protein Antigen - NBP1-85609PEP from Novus Biologicals
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LPHN1 Peptide, Human - M34GP08816H from Creative Peptides
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Latrophilin-1 (LPHN1), partial, Recombinant Protein - MBS1123330 from MyBioSource
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LPHN1 peptide - orb234522 from Biorbyt
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