OAS3

Gene Symbol OAS3
Entrez Gene 4940
Alt Symbol p100, p100OAS
Species Human
Gene Type protein-coding
Description 2'-5'-oligoadenylate synthetase 3, 100kDa
Other Description (2-5')oligo(A) synthase 3|(2-5')oligo(A) synthetase 3|2'-5'-oligoadenylate synthase 3|2'-5'oligoadenylate synthetase p100|2-5A synthase 3|2-5A synthetase 3|p100 OAS
Swissprots Q9Y6K5 Q9H3P5 Q2HJ14
Accessions CBI67637 CBI70412 CDI30182 EAW98024 EAW98025 Q9Y6K5 AB044545 BAB18647 AF063613 AAD28543 AK000608 AK292949 BAF85638 BC012015 BC113746 AAI13747 BG390192 BG765554 BM474470 BU558279 BU860096 W47620 XM_005253889 XP_005253946 NM_006187 NP_006178
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Present at high level in placenta trophoblast.
Top Pathways Hepatitis C, Measles, Influenza A, Herpes simplex infection

OAS3 (C-15) - sc-49866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OAS3 (H-130) - sc-99100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

OAS3 (N-18) - sc-49870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OAS3 (N-18): sc-49870. Western blot analysis of OAS3 expression in RT-4 (A), U-87 MG (B) and NCI-H1299 (C) whole cell lysates.

OAS3 (S-20) - sc-49871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-OAS3 antibody - ab154270 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-OAS3 antibody (ab154270) at 1/3000 dilution + A431 whole cell lysate at 30 µg

Anti-OAS3 antibody - ab64163 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue, staining OAS3 with ab64163 at 10 µg/ml.

Anti-OAS3 antibody - ab188111 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-OAS3 antibody (ab188111) at 2 µg/ml + A431 cell line lysate at 35 µgdeveloped using the ECL technique

Anti-OAS3 antibody - Carboxyterminal end - ab71780 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-OAS3 antibody - Carboxyterminal end (ab71780) at 1/100 dilution + A375 lysate at 12.5 µg

Anti-OAS3 / p100 Antibody (aa1070-1087) IHC-plus™ - LS-B101 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-OAS3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B101 concentration 10 ug/ml.

Anti-OAS3 / p100 Antibody (C-Terminus, AP) - LS-C245188 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus, Biotin) - LS-C245190 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus, FITC) - LS-C245191 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus, PE) - LS-C245193 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus, APC) - LS-C245189 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus, Azide-free, HRP) - LS-C247733 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (C-Terminus) - LS-C330561 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS3 / p100 Antibody (aa355-369) - LS-C305838 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
OAS3 antibody (2 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OAS3 / p100 Antibody (aa1056-1087) - LS-C100475 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-OAS3 C-term Antibody is used in Western blot to detect OAS3 in A375 lysate.

OAS3 Antibody - NBP1-85841 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OAS3 Antibody [NBP1-85841] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4

OAS3 Antibody - NBP1-85845 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OAS3 Antibody [NBP1-85845] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

OAS3 Antibody - NBP2-19617 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OAS3 Antibody [NBP2-19617] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE gel, diluted at 1:3000.

Anti-OAS3 antibody produced in rabbit - HPA041253 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OAS3: <B>Cat. No. HPA041253</B>: Immunohistochemical staining of human breast shows moderate cytoplasmic positivity in glandular cells.

Anti-OAS3 antibody produced in rabbit - HPA041372 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OAS3: <B>Cat. No. HPA041372</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in cells in tubules.

Anti-OAS3 (C-term) antibody produced in rabbit - SAB1300335 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OAS3 (C-term) Antibody: <B>Cat. No. SAB1300335</B>: OAS3 in A375 cell line lysates with Anti-OAS3 (C-term) Antibody at 4.0 μg/mL.

OAS3-Antibody-C-term - AP6228a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
The anti-OAS3 C-term Antibody (Cat.#AP6228a) is used in Western blot to detect OAS3 in A375 lysate.
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