| Gene Symbol |
OAS3
|
| Entrez Gene |
4940
|
| Alt Symbol |
p100, p100OAS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
2'-5'-oligoadenylate synthetase 3, 100kDa
|
| Other Description |
(2-5')oligo(A) synthase 3|(2-5')oligo(A) synthetase 3|2'-5'-oligoadenylate synthase 3|2'-5'oligoadenylate synthetase p100|2-5A synthase 3|2-5A synthetase 3|p100 OAS
|
| Swissprots |
Q9Y6K5 Q9H3P5 Q2HJ14
|
| Accessions |
CBI67637 CBI70412 CDI30182 EAW98024 EAW98025 Q9Y6K5 AB044545 BAB18647 AF063613 AAD28543 AK000608 AK292949 BAF85638 BC012015 BC113746 AAI13747 BG390192 BG765554 BM474470 BU558279 BU860096 W47620 XM_005253889 XP_005253946 NM_006187 NP_006178
|
| Function |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Present at high level in placenta trophoblast.
|
| Top Pathways |
Hepatitis C, Measles, Influenza A, Herpes simplex infection
|